Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0017638 (
glioma
)
30,880
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Zinc finger protein 281
(
ZNF281
) has been characterized as a tumor suppressive lncRNA in
glioma
. The present study aimed to analyze the functionality of
ZNF281
in osteosarcoma (OS). It was demonstrated that
ZNF281
was downregulated in OS tissue specimens and predicted the survival of patients with OS. In tissues from patients with OS,
ZNF281
was negatively associated with rho-associated coiled-coil containing protein kinase 1 (ROCK1), but positively associated with miR-144. In the U2OS cell line,
ZNF281
overexpression mediated the upregulation of miR-44 and downregulation of ROCK1. miR-144 overexpression led to the downregulation of ROCK1, but failed to affect
ZNF281
. Expression of
ZNF281
and miR-144 resulted in decreased cell migration and invasion, while ROCK1 overexpression resulted in increased invasion and migration of OS cells. In addition, ROCK1 overexpression attenuated the effects of
ZNF281
and miR-144 overexpression. Thus,
ZNF281
may downregulate ROCK1 by upregulating miR-144 and inhibit cancer cell invasion and migration in OS.
...
PMID:LncRNA-zinc finger protein 281 downregulates rho-associated coiled-coil containing protein kinase 1 by upregulating miR-144 in osteosarcoma. 3286 12
