Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0017638 (
glioma
)
30,880
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Protease nexin-I (
PN-I
, Mr approximately 43,000) is representative of a newly described class of cell-secreted protease inhibitors.
PN-I
has been purified to apparent homogeneity, partially sequenced, and monospecific antibodies have been raised against it.
PN-I
is a potent inhibitor of urokinase, thrombin, plasmin, and trypsin. In addition, cells have specific receptors that mediate the uptake of covalently linked complexes formed between
PN-I
and its protease substrates. In the present studies, we have investigated the relationship between human
PN-I
and a protease inhibitor derived from C6
glioma
cells in culture that has neurite-promoting activity. On the basis of co-purification on heparin-Sepharose, identical molecular weight, antibody cross-reactivity, and receptor cross-reactivity, we conclude that
PN-I
and the
glioma
-cell-derived inhibitor are equivalent molecules.
...
PMID:The glioma cell-derived neurite promoting activity protein is functionally and immunologically related to human protease nexin-I. 304 Jul 80
