Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0017638 (
glioma
)
30,880
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Downbeat nystagmus
(
DBN
) is a primary position nystagmus with the fast phase in a downward direction. It is a rare but distinctive disorder of ocular motility and usually localizes the lesion at the posterior fossa. Four patients with
DBN
were seen in the department. One had a medullary
glioma
, and another congenital basilar invagination. The other two were initially diagnosed as demyelinating disease. One was subsequently found to have Arnold Chiari Malformation on magnetic resonance imaging (MRI). Review of the literature showed that cerebellar ectopia (Arnold Chiari Malformation) is the commonest cause of
DBN
. However 1/3 of reported cases have no obvious cause.
DBN
is of such high localizing value that we recommend MRI of cervicomedullary junction for all patients with
DBN
to exclude cerebellar ectopia or medullary lesion.
...
PMID:The localizing value of downbeat nystagmus. 258 20
