Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0017638 (
glioma
)
30,880
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The basic helix-loop-helix transcription factors
oligodendrocyte transcription factor 1
(
OLIG1
) and OLIG2 are structurally similar and, to a first approximation, coordinately expressed in the developing CNS and postnatal brain. Despite these similarities, it was apparent from early on after their discovery that
OLIG1
and OLIG2 have non-overlapping developmental functions in patterning, neuron subtype specification and the formation of oligodendrocytes. Here, we summarize more recent insights into the separate roles of these transcription factors in the postnatal brain during repair processes and in neurological disease states, including multiple sclerosis and malignant
glioma
. We discuss how the unique functions of
OLIG1
and OLIG2 may reflect their distinct genetic targets, co-regulator proteins and/or post-translational modifications.
...
PMID:Separated at birth? The functional and molecular divergence of OLIG1 and OLIG2. 2316 59
