Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0017638 (
glioma
)
30,880
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The myelodysplasia/myeloid leukemia factor 1-interacting protein
MLF1IP
is a novel gene which encodes for a putative transcriptional repressor. It is localized to human chromosome 4q35.1 and is expressed in both the nuclei and cytoplasm of cells. Northern and Western blot analyses have revealed
MLF1IP
to be present at very low amounts in normal brain tissues, whereas a number of human and rat glioblastoma (GBM) cell lines demonstrated a high level expression of the MLF1IP protein. Immunohistochemical analysis of rat F98 and C6 GBM tumor models showed that
MLF1IP
was highly expressed in the tumor core where it was co-localized with MLF1 and nestin. Moreover,
MLF1IP
expression was elevated in the contralateral brain where no tumor cells were detected. These observations, together with previous data demonstrating a role for
MLF1IP
in erythroleukemias, suggest a possible function for this protein in
glioma
pathogenesis and potentially in other types of malignancies.
...
PMID:Regulation of myeloid leukemia factor-1 interacting protein (MLF1IP) expression in glioblastoma. 1589 39
