Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0017638 (glioma)
 30,880 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An optic chiasm glioma may cause loss of vision, endocrine disturbances, hydrocephalus and cerebral ischemia due to its proximity to the pituitary, hypothalamus, III ventricle and internal carotids. A 3-month-old infant with optic chiasm glioma developed hypopituitarism and inappropriate secretion of antidiuretic hormone with plasma hypo-osmolality. The cerebrospinal fluid (CSF) protein concentration was markedly elevated. The impairment of fluid absorption via arachnoid villi and peritoneum by the high protein content, and reversed osmotic gradient between protein-rich CSF and hypo-osmolar plasma may have contributed to both nonobstructive hydrocephalus and recurrent ascites following ventriculoperitoneal shunting. Cerebral ischemia from carotid compression may have led to cerebral atrophy.
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PMID:Optic chiasm glioma associated with inappropriate secretion of antidiuretic hormone, cerebral ischemia, nonobstructive hydrocephalus and chronic ascites following ventriculoperitoneal shunting. 179 May 31

The intracellular volume of neoplastic brain cells was investigated with regard to the effects of hypo-osmolality and hyperosmolality utilizing double isotopic labeling with 3-0-methyl-D-glucose or tritiated water to measure the total volume of the pellet and inulin or polyethyleneglycol to measure the extracellular volume of the pellet. The cellular pellets were rapidly separated from the incubation medium by centrifugation after addition of an oil mixture. After 60 minutes incubation in Hanks balanced salt medium, the intracellular volume was 7.50 +/- 0.64, 8.48 +/- 0.19, and 2.97 +/- 0.18 ml H2O per 10(6) packed cells for C-6 glioma cells, N18TG-2 neuroblastoma cells, and NG108-15 neuroblastoma X glioma hybrid cells, respectively. The extracellular trapped space of these cultured cells was about one third of the intracellular volume. The intracellular volume of C-6 glioma cells was increased in hypotonic environment, whereas it was decreased with hyperosmolality. Both intracellular sodium and potassium were increased with increased osmolality of the incubation media. These data indicate iso-osmotic regulation by tumor cells, i.e., there is a good correlation between the intracellular volume, intracellular cations and lactate levels of C-6 glioma cells under various osmotic conditions.
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PMID:Intracellular volume of osmotically regulated C-6 glioma cells. 717 79

Rat C6 glioma cells undergo regulatory volume decrease (RVD) following sudden exposure to hypo-osmolality, but little or no regulatory volume increase (RVI) is observed when cells cultured in hypo-osmotic media are suddenly returned to isoosmolality. Because C6 glioma cells would rarely be exposed to sudden large changes in osmolality in vivo, we examined the ability of these cells to maintain their volume, termed 'isovolumetric regulation', when exposed to gradual changes in osmolality. When osmolality was gradually reduced by reduction of NaCl concentration from 300 to 250 mOsmol/kg at a rate of 0.4 mOsmol/kg/min or less cells were able to maintain their volume, while at higher rates, the cells swelled. Cells which were cultured in hypo-osmotic (200 mOsmol/kg) media for 3 days exhibited isovolumetric regulation at rates of osmolality increase of 0.5 mOsmol/kg/min or less over the range of 200-250 mOsmol/kg. We conclude that rat C6 glioma cells can sensitively regulate their volume over the osmolality range of pathophysiologic interest at rates of osmolality change which are faster than those generally seen in clinical conditions.
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PMID:Isovolumetric regulation of rat glial cells during development and correction of hypo-osmolality. 1082 39