Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0017638 (glioma)
 30,880 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We studied the frequency of oligoclonal immunoglobulin G bands in the cerebrospinal fluid (CSF) of patients with various neurological diseases. We used a micromethod employing sodium dodecyl sulfate polyacrylamide gel electrophoresis that required only 50 microliters of unconcentrated CSF. Oligoclonal bands were detected in the CSF of 95% of the patients with multiple sclerosis, 90% with subacute sclerosing panencephalitis, and 100% with herpes simplex encephalitis, but less frequently in other central nervous system infections. No oligoclonal bands were detected in the CSF of patients with Parkinson, Huntington, Creutzfeldt-Jakob, or herniated disc diseases. Bands were detected in some patients with Alzheimer disease, cerebrovascular accident, idiopathic vertigo, idiopathic seizures, amyotrophic lateral sclerosis, polyneuropathy, and central nervous system glioma. Patients with other conditions infrequently had positive bands. The determination of oligoclonal bands is a useful aid in the diagnosis of multiple sclerosis, subacute sclerosing panencephalitis, and herpes simplex encephalitis. The presence of oligoclonal bands indicates an immunological response but is not diagnostic for a particular condition.
 ...
PMID:Oligoclonal IgG bands in cerebrospinal fluid in various neurological diseases. 683 75

Gadolinium contrast agents represent one of the most important advances in MR imaging of spinal disease. Many abnormalities that affect the epidural, intradural extramedullary, and intramedullary compartments demonstrate contrast enhancement, the pattern of which often provides specific diagnostic information. This is particularly true of neoplastic diseases such as primary glioma and leptomeningeal tumor spread. Gadolinium contrast also finds vital application in differentiating herniated disc from epidural fibrosis in the failed-back surgery syndrome, as well as hypointense disc from enhancing tumor in select cases. Certain demyelinating and inflammatory processes also have predictable MR manifestations that facilitate accurate diagnosis.
 ...
PMID:Clinical experience with gadolinium contrast agents in spinal MR imaging. 848 31