Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0017638 (glioma)
 30,880 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A retrospective study of 72 consecutive and nonrandomized patients with malignant glial tumors is presented. The influence of age, sex, location of tumor, initial presenting symptoms, symptomatic preoperative interval, reoperation, extent of tumor removal, histological subtype of tumor, lymphocyte infiltration, and different treatments upon survival time has been evaluated and statistically analyzed. Age was inversely associated with survival with a strong statistical significance (p = 0.0001). Headache was the most common (67%) initial symptom; aphasia and seizure were both present in 45.3% of patients. Initial presenting symptoms had no effect upon survival. Parietal lobe and lymphocyte infiltration had marginally negative effects upon survival (p = 0.097 and p = 0.10 respectively). The amount of tumor removal was marginally associated with an improved survival (p = 0.07). Radiation therapy was strongly associated with an improved survival time (p = 0.0007). The addition of chemotherapy did not affect the survival (perhaps reflecting the small number of patients and inadequate chemotherapy). There was an obvious beneficial effect of reoperation upon survival time, if the patient lived and underwent reoperation later than 16 months after the initial operation (slow-growing tumor). Although median and mean survival times (10 and 20.34 months respectively, SD 7.45 months) were similar to most series reported, our rates of survival (20%, 12.5%, and 7.5% at 2, 3, and 5 years, respectively) were notably higher.
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PMID:Malignant gliomas of the brain. A retrospective study. 373 21

Parietal lobe functions include somesthesia, language, calculation, self-motion perception, and visuospatial awareness. In this video, the authors show the intraoperative mapping of a left parietal lobe for a low-grade glioma resection. Standard sensory and language mapping were performed. Interestingly, by using the "Line Bisection" task, subcortical stimulation of the gyrus angularis was repeatedly associated with ipsilateral spatial neglect, often described in the right parietal lobe. In a similar way, subcortical stimulation in a more posterior point elicited episodes of vertigo, probably due to stimulation of the superior longitudinal fasciculus. Both findings were useful to define the functional limit of the resection. The video can be found here: https://youtu.be/qgGDRW_6u0A .
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PMID:Mapping visuospatial and self-motion perception functions in the left parietal lobe. 3026 56