Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0017638 (glioma)
 30,880 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Particular attention to airway problems must be paid to any child with a craniofacial anomaly. Knowledge of the potential for upper airway obstruction in children with craniofacial anomalies, early recognition of the signs of obstruction, and prompt treatment are extremely important aspects of the treatment plan for each patient. An infant with choanal atresia or a nasal glioma will need definitive repair of his specific deformity to ensure the airway prior to consideration of any other problem. Similarly, the child with severe mandibular hypoplasia may require an early tongue-lip adhesion or tracheotomy to relieve airway distress until mandibular growth or surgical advancement enlarges the natural airway. Adenotonsillar hypertrophy may present earlier and with more severe sleep apnea in a child with an already compromised pharyngeal lumen. Early tonsillectomy and/or adenoidectomy must be considered in these patients even if this may possibly lead to velopharyngeal incompetence. Sleep apnea may also occur as a complication of the creation of a pharyngeal flap. If operative intervention for the craniofacial anomaly is contemplated, the potential for airway problems increases. The anesthetic induction and intubation are extremely difficult in the child with mandibular hypoplasia. The anesthetist and otolaryngologist must have a full range of techniques available to them to accomplish this task. If intermaxillary fixation is required postoperatively, or if the endotracheal tube is in the operative field, consideration should be given to a short-term tracheotomy to protect the airway during and after the operation. Close cooperation among the members of the craniofacial team is mandatory to prevent and/or treat any upper airway obstruction that may occur in the child with a craniofacial anomaly. Anticipation of possible airway compromise, early recognition of any existing obstruction, and prompt management of the problem are imperative to the successful diagnosis and treatment of craniofacial anomalies.
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PMID:Upper airway obstruction in craniofacial anomalies: diagnosis and management. 404 77

We encountered a young woman with severe central sleep apnea caused by a medullary glioma located slightly dorsal to and to the right of the midline, a region not generally associated with CO(2) chemosensitivity. The patient had normal spirometric readings, lung volumes, diffusing capacity, maximal inspiratory pressure, and alveolar-arterial oxygen difference. While awake, she displayed marked irregularity in her breathing pattern; her end-tidal CO(2) (FET(CO(2))) ranged from 5.3 to 10.9%. During voluntary hyperpnea, she could quickly reduce her FET(CO(2)) to 4.2%, but her PCO(2) did not change after administration of acetazolamide or progesterone. Like patients with congenital central hypoventilation syndrome (CCHS), our patient had a relatively intact ventilatory response to exercise; her PCO(2) was high at the start of exercise and increased slightly thereafter. In contrast to CCHS patients, however, our patient had an intact hypoxic ventilatory response (DeltaVE/ DeltaSa(O(2)) = -0.37 L/min/Sa(O(2))). In further contrast to CCHS patients, our patient had a very short breathholding time and described a sensation of air hunger as the factor limiting her breathholding ability. Her heart rate and blood pressure responses to the Valsalva maneuver were normal.
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PMID:Respiratory control and respiratory sensation in a patient with a ganglioglioma within the dorsocaudal brain stem. 1085 94

A 49-year-old woman with 6 months history of body weight loss, muscle weakness, and dysarthria, was found with respiratory arrest and resuscitated in the morning of January 1999. An MRI brain scan revealed diffuse swelling and T2/FLAIR high signal intensity with mild Gadolinium enhancement in the lower pons and medulla oblongata. Although the histological diagnosis could not be obtained, glioma (astrocytoma) was suspected. In the morning of July 3rd she presented sweating and cyanosis. Her arterial oxygen saturation was 18%. When we asked her to breathe more, she kept breathing and oxygen saturation was normalized. However, she could not breathe at all when she fell asleep without stimulation. She was kept under respiratory support for 2 months. Her symptoms improved with fluctuating course after 70 Gy of radiation therapy. Ondine curse is one type of sleep apnea syndrome, defined as the selective disturbance of autonomous breathing. Surgical operation and stroke are the reported causes of this syndrome. Brainstem tumor is relatively common cause for children's Ondine curse. On the other hand, it rarely causes adult's Ondine curse as a main symptom.
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PMID:[A case of Ondine curse associated with a medullary tumor]. 1121 2

The aim of the study was to ascertain the occurrence of the sleep apnoea syndrome (SAS) in patients after pituitary afunctional adenoma operation or in patients with other affection in sella turcica region except acromegaly patients. Eighty-one patients were addressed. Sixteen patients (eight men, eight women) underwent the examination; the rest of them had no interest to be explored. Afunctional pituitary adenoma was diagnosed in twelve patients, afunctional pituitary adenoma and subsequently optic glioma in one patient, craniopharyngioma in one patient, prolactinoma in one patient and undifferentiated cystic pituitary tumour in one patient. Neurological examination was done in all patients (standardized sleep questionnaire was included). SAS was quantified using PolyMESAM. Severity of SAS were set up from the value of M index (M = ODI.delta saturation; ODI--oxygen desaturation index). Mild SAS: 40 < M < 100; middle SAS: 100 < M < 210; severe SAS: M > 210. SAS was diagnosed in 13 patients: mild SAS in three of them (average value of M index: 81.0 +/- 12.7), moderate SAS in seven patients (average value of M index: 129.0 +/- 18.7) and severe SAS in three patients (average value of M index: 790.0 +/- 563.0). Therapy by continuous positive airway pressure (CPAP) was recommended in six patients. Five of them continue in using of CPAP--four patients with good compliance. The occurrence of SAS was 16.05% in measured group, higher than in normal population.
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PMID:[The sleep apnea syndrome in hypophyseal disorders with the exception of acromegaly]. 1170 81

Surgery was performed on the medulla oblongata of two adult patients with malignant glioma. Gross total resection of the tumors, located laterally or medially in the upper half of the medulla respectively, was achieved. The patient with the medially located tumor experienced significant postoperative neurological deterioration including sleep apnea. The other patient with the laterally located tumor showed symptomatic improvement without respiratory complications. The patient with an anaplastic astrocytoma survived approximately 4 years and the patient with a glioblastoma multiforme approximately 2 years. Although the upper half of the medulla is more critical than the lower half, a lateral approach to the upper half of the medulla appears to be relatively safer than a medial approach. Some cases of focal malignant gliomas in the medulla may be amenable to gross total resection in order to achieve improved outcome. Surgery can be undertaken when a tumor is unilateral and its margin appears relatively clear on magnetic resonance images.
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PMID:Gross total surgical removal of malignant glioma from the medulla oblongata: report of two adult cases with reference to surgical anatomy. 1464 74