Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0017638 (glioma)
 30,880 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A case of Maffucci's syndrome with brain-stem tumor is reported. A 17-year-old man with a history of diplopia and unsteady gait for 5 months was admitted to our hospital on May 6, 1987. Neurological findings on admission disclosed left VIIth cranial nerve and bilateral VIIth nerve palsies and mild quadriplegia with a bilateral Babinski sign. His left limbs were deformed and disproportionally shortened since birth, and there were multiple enchondroma of the phalanges. Several bluish subcutaneous soft tumors were present on his left hand. Histological examination of a skin lesion confirmed the cavernous hemangioma. A CT scan showed diffuse symmetrical low density area in the brain-stem. No contrast enhancement was noted. Sagittal magnetic resonance imaging (MRI) demonstrated swelling of the brain stem especially in the pons and medulla oblongata. Left vertebral angiogram showed an avascular mass in the region brain stem. Brain-stem glioma being strongly suspected, both radiation therapy and chemotherapy were performed. After 66 Gy irradiation and ACNU administration, his neurological deficits gradually improved. The patient was discharged from the hospital on foot on August 7, 1987. The sagittal MRI taken on January 24, 1988 disclosed that the brain-stem swelling was apparently diminished. Maffucci's syndrome is a congenital, non-hereditary mesodermal dysplasia associated with multiple enchondromas and subcutaneous hemangioma. Although numerous tumors of the central nervous system have been described in association with Maffucci's syndrome, to our knowledge, no mention has been made of lesions in the brain-stem. The present case is an extremely rare instance of this syndrome complicated by the occurrence of a brain-stem tumor.
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PMID:[A case of Maffucci's syndrome with brain-stem tumor]. 280 30

Recently extension of malignant glioma to the spinal cord (meningeal gliomatosis: MG) has been described with increasing frequency as the advancement of the therapy for brain tumor. However, the study for clinicopathological features of MG has not been established and its therapy has still been difficult. We tried to produce experimental models of MG using nude mice and study experimental immunotherapy with human monoclonal antibody (CLN-IgG MoAb). U87-SC1 human glioma cells (5 x 10(5) in 20 microliters) were inoculated transcutaneously into the cisterna magna of BALB/c nu/nu mice using a 27-gage needle. Daily weights, neurological findings and survival time were examined. MRI scan was performed after neurological deterioration and histological examination was also performed after death. CLN-IgG MoAb was used for treatment and 15 nude mice which were inoculated with tumor cells into the cisterna magna (Day 0) were divided into three groups of 5 mice each. Group A was control group which received saline into the cisterna magna, Group B and C received 50 micrograms of CLN-IgG into the cisterna magna on Day 2 or Day 7 following inoculation of tumor cells. Efficacy of experimental immunotherapy was statistically evaluated by the difference of median survival time (MST) among three groups. All of the nude mice lost weight within 4 or 5 days after inoculation of tumor cells and developed paraplegia or tetraplegia with incontinence and died. MRI of the nude mice which showed neurological deteriorations revealed ventricular dilatation, infiltration of tumor cells to the spinal cord and spread of tumor cells into the subarachnoid space.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Experimental study on immunotherapy of meningeal gliomatosis with monoclonal antibody]. 847 56

Giant cell glioblastoma multiforme (gcGBM) is an unusual subtype of high-grade glioma (grade IV, World Health Organization classification). We report a patient with a rare acute tetraplegia, followed by lethal cardiac arrest, who had undergone a prior resection of a supratentorial gcGBM. Neuroradiological workup revealed a large, high cervical compressive leptomeningeal mass consistent with a drop metastasis. Due to the possibility of a rapid clinical deterioration in patients with high cervical cord compression, the diagnosis of drop metastasis to the spine should be considered in patients with a previous history of supratentorial GBM who present with acute diffuse motor weakness.
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PMID:Acute tetraplegia and cardiac arrest following high cervical leptomeningeal metastasis of giant cell glioblastoma. 2165 53