Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0017638 (
glioma
)
30,880
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Glioblastoma multiforme (GBM), a prevalent brain cancer with high mortality, is resistant to the conventional single-agent chemotherapy. In this study, we employed a combination chemotherapy strategy to inhibit GBM growth and addressed its possible beneficial effects. The synergistic effect of lauroyl-gemcitabine (Gem-C
12
) and honokiol (HNK) was first tested and optimized using U87 cells in vitro. Then, the hyaluronic acid-grafted micelles (HA-M), encapsulating the optimal
mole
ratio (1:1) of Gem-C
12
and HNK, were prepared and characterized. Cell-based studies demonstrated that HA-M could be transported into cells by a CD44 receptor-mediated endocytosis, which could penetrate deeper into tumor spheroids and enhance the cytotoxicity of payloads to
glioma
cells. In vivo, drug-loaded HA-M significantly increased the survival rate of mice bearing orthotopic xenograft GBM compared with the negative control (1.85-fold). Immunohistochemical analysis indicated that the enhanced efficacy of HA-M was attributed to the stronger inhibition of
glioma
proliferation and induction of apoptosis. Altogether, our findings showed advantages of combination chemotherapy of GBM using HA-grafted micelles.
...
PMID:Hyaluronic Acid-Modified Micelles Encapsulating Gem-C
12
and HNK for Glioblastoma Multiforme Chemotherapy. 2939 47
Schimmelpenning syndrome is a rare, well-defined constellation of clinical phenotypes associated with the presence of
nevus
sebaceous and multisystem abnormalities most commonly manifested as cerebral, ocular, and skeletal defects [<xref ref-type="bibr" rid="ref1">1</xref>]. A single nucleotide mutation in the HRAS or KRAS genes resulting in genetic mosaicism is responsible for the clinical manifestations of this syndrome in the majority of cases. We report a case of an adolescent boy with Schimmelpenning syndrome with a multifocal pilocytic astrocytoma. No HRAS or KRAS gene mutations were noted in the tumor on genetic sequencing. However,
glial tumors
have been associated with genetic mutations of RAS upregulation, which may imply a common pathway.
...
PMID:Is Schimmelpenning Syndrome Associated with Intracranial Tumors? A Case Report. 3087 10
Congenital nasal midline lesions are rarely observed pathologies. While relatively frequently encountered lesions are dermoid cyst,
glioma
, encephalocele, nasal polyp and epidermoid cyst, an other very rare reason is the congenital panfollicular
nevus
. The treatment of this syndrome appearing with a recurrent discharge in clinic is the surgical excision. We will hereby present the excision of the case of congenital panfollicular
nevus
with three different fistula openings.
...
PMID:Nasal Congenital Panfollicular Nevus. 3176 29
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