Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0017638 (glioma)
 30,880 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A case of progressive multifocal leukoencephalopathy (PML) is reported, detected at autopsy of a 30-year-old patient. The clinical picture was characterized by a progressive course of mental deterioration and ingravescent neurological symptoms. The patient was HIV-negative. He died of bronchopneumonia, after a clinical course of 13 months. Autopsy disclosed pulmonary tuberculosis with involvement of regional lymph nodes. In the brain, besides numerous PML-foci of varying age and structure, a pleomorphic astrocytoma was found in the white matter of the right parietal lobe. In the brain stem glial proliferation resembling diffuse gliomatosis was also present. In situ hybridization revealed Papova-virus (JCV) in oligoglial nuclei, but not in neoplastic astrocytes. This is the third report on the concomitant occurrence of PML and glioma in man.
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PMID:Progressive multifocal leukoencephalopathy and gliomas in a HIV-negative patient. 130 Jun 8

We present the case of a 28-year-old man who underwent craniotomy and subsequent radiotherapy for a suprasellar craniopharyngioma at the age of 8 years. The patient suffered from a severe pituitary deficiency until his death. The cause of death was a bronchopneumonia. At necropsy epithelial tissue characteristic of craniopharyngioma was no longer found, but instead a subependymoma of the third ventricle. Up to now most reported primary central nervous system tumors associated with subependymomas were ependymomas. However, in 1 case very similar to ours a subependymoma was associated with a craniopharyngioma. Furthermore, only rare examples of subependymomas of the third ventricle have been reported. The growth of a subependymoma might have been induced by intense reactive gliosis as a response of the adjacent brain tissue to the craniopharyngioma. However, in view of the repeated post-operative irradiation in our case the possibility of radiation-induced glioma has also to be considered.
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PMID:Subependymoma of the third ventricle after partial resection of a craniopharyngioma and repeated postoperative irradiation. 892 98