Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0017638 (
glioma
)
30,880
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Glioma
is the most common malignant primary brain tumors with poor prognosis. Genome wide association studies (GWAS) of
glioma
in populations with Western European ancestry were completed in the US and UK. However, our previous results strongly suggest the genetic heterogeneity could be important in
glioma
risk. To systematically investigate
glioma
risk-associated variants in Chinese population, we performed a multistage GWAS of
glioma
in the Han Chinese population, with a total of 3,097
glioma
cases and 4,362 controls. In addition to confirming two associations reported in other ancestry groups, this study identified one new risk-associated locus for
glioma
on chromosome 12p11.23 (rs10842893, p
meta
= 2.33x10-12,
STK38L
) as well as a promising association at 15q15-21.1 (rs4774756, p
meta
= 6.12x10-8, RAB27A) in 3,097
glioma
cases and 4,362 controls. Our findings demonstrate two novel association between the
glioma
risk region marked by variant rs10842893 and rs4774756) and
glioma
risk. These findings may advance the understanding of genetic susceptibility to
glioma
.
...
PMID:Two novel genetic variants in the STK38L and RAB27A genes are associated with glioma susceptibility. 3071 41
