Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0017638 (glioma)
 30,880 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Members of the NDRG (N-Myc downstream-regulated) gene family have been shown to play a variety of roles in human malignancies. In the present study, we examined the expression of NDRG2 protein in glioma samples of WHO grades I-IV. We also investigated the association between NDRG2 expression and survival. Immunohistochemical analysis was used to measure NDRG2 protein expression in 316 specimens of human glioma and 41 normal control tissues. Survival analysis was performed using the Kaplan-Meier method and Cox's proportional hazards model. We found that NDRG2 expression was reduced in glioma relative to normal tissue, and that NDRG2 expression decreased with increasing glioma grade. Kaplan-Meier analysis showed that patients without NDRG2 expression had a lower survival rate than other patients. Multivariate analysis showed that NDRG2 expression was an independent prognostic factor for overall survival of patients with glioma. The present study provides the first evidence that NDRG2 expression is decreased in gliomas, indicating that NDRG2 may play an inhibitory role during the development of gliomas. NDRG2 expression may also be a significant and independent prognostic indicator for glioma.
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PMID:Decreased expression of NDRG2 is related to poor overall survival in patients with glioma. 2187 76

NDRG2, a member of the N-Myc downstream-regulated gene family, was shown to be a putative tumor suppressor gene in glioblastoma and other cancers. Through a bioinformatic analysis, we found that NDRG2 protein contains an acyl carrier domain. In the current study, we therefore hypothesized that NDRG2 may play an important role in the regulation of histone acetylation. Treatment of U251 and U87 glioma cells with trichostatin A, an inhibitor of histone deacetylase, upregulated the expression of NDRG2 and acetylated forms of histones H3 and H4, reduced tumor cell viability and arrested the cell cycle at the G1/G0 phase. Overexpression of NDRG2 by transfecting glioma cells with adenovirus containing the NDRG2 gene upregulated the levels of acetylated forms of H3 and H4 whereas inhibition of NDRG2 expression by siRNA-mediated knockdown downregulated the level of histone acetylation. Furthermore, NDRG2 siRNA significantly reduced the level of histone acetylation induced by trichostatin A. Taken together, these data demonstrate that NDRG2 can regulate the level of histone acetylation to control glioma cell growth.
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PMID:Regulation of histone acetylation by NDRG2 in glioma cells. 2191 36