Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0017638 (
glioma
)
30,880
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Mammalian mitochondrial ribosomal proteins are functionally involved in protein synthesis in mitochondrion. Recently numerous studies have illuminated the role of mitochondrion in cancer development. However, the precise function of
mitochondrial ribosomal protein L42
(
MRPL42
) remains unclear. Here in the present study, we identified
MRPL42
as a novel oncogene in
glioma
. By analyzing the Cancer Genome Atlas (TCGA) database, we first found that
MRPL42
was significantly up-regulated in glioma tissues compared with normal tissues. Functionally, we silenced
MRPL42
in
glioma
cells and revealed that
MRPL42
knockdown largely blunted the proliferation of U251 and A172 cells. Mechanistically, our results suggested that
MRPL42
silencing resulted in increased distribution of cell cycle in G
1
and G
2
/M phases, while the S-phase decreased. In addition, the apoptosis and caspase3/7 activity were both activated after
MRPL42
knockdown. Taken together,
MRPL42
is a novel oncogene in
glioma
and might help us develop promising targetted therapies for
glioma
patients.
...
PMID:Knockdown of MRPL42 suppresses glioma cell proliferation by inducing cell cycle arrest and apoptosis. 2953 Oct 15
