Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0017636 (glioblastoma)
 18,345 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
Mol 1422
Sep 1095
p53 1015
EGFR 545
epidermal growth factor receptor 524
methylguanine-DNA methyltransferase 493
MRI 482
vascular endothelial growth factor 397
PTEN 391
AKT 366
caspase-3 365
PI3K 362
GBM 344
mTOR 336
glial fibrillary acidic protein 330
CD133 316
IDH1 298
cytokine 263
Bcl-2 262
VEGF 257
tyrosine kinase 252
ERK 221
IDH 210
MAPK 207
STAT3 196
p21 179
histone 178
catenin 175
NMR 160
ATP 152
ERK1 152
receptor tyrosine kinase 149
matrix metalloproteinase 147
tumor necrosis factor 145
isocitrate dehydrogenase 137
interferon 132
methyltransferase 128
isocitrate dehydrogenase 1 127
endoplasmic reticulum 126
collagen 125
phosphatase 124
epidermal growth factor 123
Ki-67 119
PARP 116
vimentin 116
MMP-2 115
EGF 114
CD44 114
cyclin D1 114
p38 111
CD8 110
fibronectin 109
IL-6 106
PEG 103
ACS 103
UTR 102
VEGFR2 100
nestin 99
BRAF 98
p16 98
histone deacetylase 97
proteasome 97
annexin V 95
cytochrome c 94
SOX2 93
MMP-9 93
survivin 93
CDKN2A 92
platelet-derived growth factor 92
JNK 90
caspase-8 90
MET 88
ROS 87
IFN 86
glycoprotein 85
Nestin 84
fused 84
thymidine kinase 83
MDM2 82
DNA methyltransferase 82
protein kinase B 80
CXCR4 80
PDGF 80
caspase-9 79
CDK4 79
TNF 78
IL-8 77
EGF receptor 76
MEK 76
chemokine 76
phosphatidylinositol 3-kinase 75
LC3 74
ubiquitin 74
focal adhesion kinase 72
TERT 72
colon carcinoma 70
p27 70
c-Myc 70
CD4 70
O6-methylguanine-DNA methyltransferase 69
urokinase-type plasminogen activator 69
P-glycoprotein 69
extracellular signal-regulated kinase 67
ATRX 67
RhoA 67
Rho 66
DNA-dependent protein kinase 66
PDGFRA 66
phosphoinositide 3-kinase 66
E-cadherin 66
CSF 65
Epidermal growth factor receptor 65
H2AX 64
MIB 64
mutant p53 64
phosphatase and tensin homolog 63
IDH2 62
tumour suppressor 62
Fas 62
PD-L1 62
MMP9 60
PDGFR 60
proliferating cell nuclear antigen 59
N-cadherin 59
p65 58
PD-1 58
osteosarcoma 58
signal transducer and activator of transcription 3 58
polypeptide 57
histone H3 55
TRAIL 55
rhabdomyosarcoma 55
CD31 54
CXCL12 54
platelet-derived growth factor receptor 53
cage 53
vascular endothelial growth factor A 53
cyclin 52
CD34 52
c-Jun 52
ATM 51
PKC 51
interleukin-6 51
MMP2 50
insulin 50
hepatocyte growth factor 49
ALA 49
Vascular endothelial growth factor 49
lymphoid 48
FAK 48
EZH2 48
NF1 47
IL-2 47
c-Met 47
membrane-bound 47
GSH 47
threonine 46
telomerase reverse transcriptase 46
PC-3 46
She 46
more...
Disease
glioblastoma 18345
tumor 8956
cancer 7536
glioma 4872
Glioblastoma 2926
brain tumor 2456
glioblastoma multiforme 1602
tumor growth 1266
astrocytoma 1009
tumorigenesis 747
tumor progression 660
brain cancer 520
melanoma 503
breast cancer 492
anaplastic astrocytoma 440
carcinoma 408
neuroblastoma 360
metastases 340
oligodendroglioma 324
medulloblastoma 310
lung cancer 254
adenocarcinoma 249
aggressiveness 238
meningioma 238
leukemia 216
prostate cancer 190
carcinogenesis 172
primary tumor 169
hepatocellular carcinoma 157
ependymoma 147
tumor angiogenesis 146
gliosarcoma 144
colorectal cancer 142
lymphoma 141
herpes simplex 136
colon cancer 131
intracranial tumors 118
MCF 118
cytomegalovirus 118
sarcoma 116
lung carcinoma 111
Alzheimer's disease 110
ovarian cancer 108
squamous cell carcinoma 104
tumor initiation 104
pancreatic cancer 101
solid tumor 100
tumor vasculature 98
non-small cell lung cancer 95
renal cell carcinoma 93
CNS tumors 92
retinoblastoma 82
brain metastases 81
epilepsy 76
thrombocytopenia 71
ATRX 67
residual disease 66
schwannoma 66
ATM 65
osteosarcoma 65
primitive neuroectodermal tumor 65
multiple myeloma 64
multiple sclerosis 61
gastric cancer 61
fibrosarcoma 60
suicide 60
SCID 59
acute myeloid leukemia 57
primitive neuroectodermal tumor 57
HIV 56
aggression 55
stroke 54
hydrocephalus 53
Blocking 52
hypertension 52
cervical cancer 50
GSH 47
Gliosarcoma 47
B-cell lymphoma 46
diabetes 46
mimicry 45
ganglioglioma 44
rhabdomyosarcoma 44
adult brain tumor 42
bladder cancer 39
ischemia 39
hemiparesis 38
cold 38
pituitary adenoma 38
liver cancer 37
brain edema 37
AS1 37
myelosuppression 36
chronic myeloid leukemia 36
neutropenia 36
depression 36
epithelial ovarian cancer 36
AIDS 36
immunodeficiency 35
NOD 35
infectious diseases 34
liver cancer 34
Parkinson's disease 34
MRS 34
HGF 33
neurofibromatosis 33
EMT 33
Malignant glioma 33
primary central nervous system lymphoma 32
encephalitis 32
lymphopenia 31
acute promyelocytic leukemia 31
Hodgkin's disease 31
virus infection 30
PNET 30
adult glioblastoma 30
WT1 30
ARF 29
DDP 29
acute lymphoblastic leukemia 29
leukopenia 28
head and neck cancer 28
meningitis 28
fits 28
neoplastic transformation 28
hematologic malignancies 26
teratoma 26
hemangioblastoma 26
schizophrenia 26
mesothelioma 25
giant cell glioblastoma 25
germinoma 24
Infection 24
endometrial cancer 24
measles 24
craniopharyngioma 23
dementia 23
SDS 23
Tumour necrosis 23
pheochromocytoma 23
APC 23
MTS 23
PNET 22
cognitive impairment 22
CNS cancer 22
renal cancer 22
TEM 21
PML 21
TEM 21
diphtheria 21
meninges 21
aphasia 20
neurofibromatosis type 1 20
tuberous sclerosis 19
plaque 19
rash 19
Turcot syndrome 19
confusion 19
CEM 18
NAME 18
more...
Symptom
seizures 129
headache 119
pain 48
vomiting 43
weakness 39
nausea 32
starvation 32
fatigue 31
HSA 26
diarrhea 26
collapse 23
ataxia 18
anesthesia 18
exhaustion 18
nausea and vomiting 12
numbness 10
anorexia 9
dysarthria 9
hemiplegia 9
sleepiness 8
dizziness 8
paresis 7
acidity 7
constipation 6
Ill 6
dyspnea 5
blurred vision 5
tremor 5
paraparesis 5
back pain 5
agitation 4
tonic-clonic seizure 4
memory loss 4
erythema 4
vertigo 4
partial seizure 4
abdominal pain 4
low back pain 4
spasm 4
neck pain 4
lethargy 4
cough 3
ophthalmoplegia 3
flushing 3
consciousness disturbance 3
Scratch 3
chills 3
chest pain 3
syncope 2
paresthesia 2
tinnitus 2
respiratory distress 2
asthenia 2
analgesia 2
insomnia 2
discomfort 2
discomfort 2
dry skin 2
masculinization 2
eye pain 2
cachexia 2
ataxic gait 2
general problem 2
hypotonia 2
angina 1
apathy 1
CSR 1
photophobia 1
chronic cough 1
anosmia 1
Psychiatric symptoms 1
testicular pain 1
gumma 1
dental pain 1
productive cough 1
torticollis 1
facial droop 1
arthralgia 1
fasciculation 1
ketonuria 1
abnormal gait 1
gustatory hallucination 1
Noise-induced hearing loss 1
frequent urination 1
spasticity 1
neuralgia 1
Signs and Symptoms 1
neck stiffness 1
hoarseness 1
hyperoxia 1
cancer pain 1
hypercapnia 1
thinning 1
overweight 1
hyperesthesia 1
leg edema 1
inanition 1
functional recovery 1
Flare 1
bone pain 1
lightheadedness 1
hypothermia 1
eds 1
hypocapnia 1
Chronic intractable pain 1
rigors 1
skin irritation 1
epigastric pain 1
meningism 1
catatonia 1
non-productive cough 1
ENT 1
cerebellar ataxia 1
splenomegaly 1
asterixis 1
orthopnea 1
Drug
Bevacizumab 123
lysine 112
ROS 86
CSF 81
ALA 47
IL-2 47
IFN-gamma 43
ascorbate 31
NVP 24
Monit 22
uPA 21
Taxol 20
p75 20
IFN-beta 19
Imatinib 19
Irinotecan 18
ABC 17
CPT-11 17
MRC 16
L-tyrosine 15
Gliadel 15
MAP 15
Gefitinib 14
Gleevec 14
GEO 14
ROC 13
Erlotinib 13
Glutathione 13
Etoposide 12
Cilengitide 12
citric acid 12
Vorinostat 12
CAM 11
Gel 11
Paraffin 11
NADH 11
G-CSF 11
CTX 11
Temodal 10
vitamin E 10
caffeine 10
Arsenic trioxide 10
ETS 9
Gelatin 9
TTC 9
FAD 8
Dasatinib 8
Sorafenib 8
G418 8
Dermatol 8
Nitric Oxide 6
Spectrum 6
TAT 6
ADM 6
CTX 6
DPA 6
CTX 6
Penfluridol 6
Bortezomib 6
Retinoic acid 6
Adriamycin 6
RFP 6
Parkin 5
Cetuximab 5
Simvastatin 5
PDGF B-chain 5
CTC 5
Asn 5
PTC 5
DNase I 5
Parkin 5
CTC 5
Axitinib 5
ZnO 5
Photofrin 5
Heme 5
Fluorescein 5
AZT 4
Photofrin II 4
Docetaxel 4
CDX 4
Ethanol 4
Fluorescein 4
Kenyan 4
Forskolin 4
Mutagen 4
Zoledronic acid 4
Ouabain 4
CED 4
CDX 4
DEX 4
Vatalanib 4
Fotemustine 4
AZT 4
Vandetanib 4
Rutin 3
Nexavar 3
Ciglitazone 3
NaI 3
IL-1ra 3
Aloe 3
Lovastatin 3
Avasimibe 3
Indomethacin 3
NaI 3
ETA 3
MDM 3
ADR 3
Itraconazole 3
Bayer 3
NaI 3
NaI 3
Activin 3
Herceptin 3
CaCl2 3
Estrogens 3
Acyclovir 3
Albumin 3
Verteporfin 3
Biopolymers 3
CaCl2 3
CDP 3
CaCl2 3
Cardiovasc 3
Doxycycline 3
Trifluoperazine 3
Spectrum 3
Ganciclovir 3
CPM 3
Histamine 3
Flavopiridol 2
Carmofur 2
Silica 2
anti-CD33 2
Ilomastat 2
Dalteparin 2
CPR 2
Panitumumab 2
Fragment 2
Amiloride 2
VCR 2
CET 2
PMEA 2
Norplant 2
Oxaliplatin 2
Ceredase 2
Magnevist 2
Diamminedichloroplatinum 2
NBT 2
CFS 2
Troglitazone 2
Emodin 2
Cerezyme 2
Romidepsin 2
VCR 2
Valganciclovir 2
TMS 2
TAC 2
Pemetrexed 2
Zoledronic acid 2
more...
Enzyme
ERK 1120
mitogen-activated protein kinase 554
caspase-3 280
luciferase 265
focal adhesion kinase 260
protein kinase 215
PARP 140
isocitrate dehydrogenase 139
isocitrate dehydrogenase 137
protein kinase C 108
ACS 104
MEK 101
proteasome 99
DNA methyltransferase 84
thymidine kinase 83
phosphatidylinositol 3-kinase 75
urokinase-type plasminogen activator 74
P-glycoprotein 73
caspase-8 69
caspase-9 67
phosphoinositide 3-kinase 66
AMP-activated protein kinase 62
reverse transcriptase 61
topoisomerase 47
calcineurin 46
cathepsin B 44
topoisomerase 44
AMPK 43
cdc2 42
AMPK 40
MMP 40
DNA ligase 39
DNA ligase 39
ATPase 38
catalase 37
superoxide dismutase 36
GSK 36
lactate dehydrogenase 34
trypsin 30
phospholipase C 29
thrombin 29
peroxidase 29
PDK1 28
RNA polymerase 27
APC 23
collagenase 23
glutathione S-transferase 22
RNase 21
RNase 21
matrix metalloproteinase 2 21
demethylase 20
glyceraldehyde-3-phosphate dehydrogenase 19
glutathione peroxidase 18
endonuclease 18
plasmin 18
transcriptase 18
beta-galactosidase 18
firefly luciferase 17
chloramphenicol acetyltransferase 17
ribonucleotide reductase 17
alkaline phosphatase 17
cytosine deaminase 16
ribonucleotide reductase 16
complex I 16
IKK 15
polo-like kinase 1 15
carbonic anhydrase 14
alanine aminotransferase 14
phosphodiesterase 14
pyruvate kinase 14
indoleamine 2,3-dioxygenase 13
histone demethylase 12
5'-nucleotidase 12
aldehyde dehydrogenase 12
aldehyde dehydrogenase 12
aldehyde dehydrogenase 12
aldehyde dehydrogenase 12
aldehyde dehydrogenase 12
pyruvate dehydrogenase 11
pyruvate dehydrogenase 11
ornithine decarboxylase 11
MAP 11
glutaminase 11
NADPH oxidase 11
chitinase 11
pyruvate dehydrogenase 11
granzyme B 11
NADPH oxidase 11
cathepsin D 11
NO synthase 10
thioredoxin reductase 10
MDR 10
arginase 10
glutathione reductase 9
tissue plasminogen activator 9
glyceraldehyde-3-phosphate dehydrogenase 9
CD10 9
succinate dehydrogenase 9
matrix metalloproteinase 9 9
farnesyltransferase 9
neuraminidase 9
HK2 9
lipoxygenase 8
chymotrypsin 8
NQO1 8
aspartate aminotransferase 8
prostate-specific membrane antigen 8
protein phosphatase 2A 8
dihydrofolate reductase 8
farnesyltransferase 8
NOS 8
phospholipase A2 8
furin 8
glyceraldehyde-3-phosphate dehydrogenase 8
enolase 7
glyceraldehyde-3-phosphate dehydrogenase 7
IMP dehydrogenase 7
kinesin 7
adenosine deaminase 7
adenosine deaminase 7
glyceraldehyde-3-phosphate dehydrogenase 7
MMP-3 7
hyaluronidase 7
lysozyme 7
histone acetyltransferase 7
glutamine synthetase 7
ATP synthase 7
Alternating 7
monoamine oxidase 7
PAM 6
ALDH 6
methylthioadenosine phosphorylase 6
adenylate cyclase 6
DNase 6
carboxylesterase 6
cathepsin L 6
transglutaminase 6
TAT 6
TdT 6
CYP3A4 6
DNA polymerase 6
DCF 6
renin 6
cytochrome oxidase 6
acetylcholinesterase 6
CPT 6
ricin 6
CGT 5
cholesterol acyltransferase 5
caspase-1 5
peroxiredoxin 5
heme oxygenase 5
nicotinamide phosphoribosyltransferase 5
glucosylceramide synthase 5
deaminase 5
hyaluronidase 5
ribonuclease 5
caspase-7 5
MEKK1 5
tyrosinase 5
more...
Compound
DNA 1925
Dec 1124
Clin 725
oxygen 538
tyrosine 310
MTT 289
Temozolomide 273
glucose 238
calcium 202
water 184
PEG 170
arginine 162
iron 157
ATP 152
sodium 151
methionine 144
lysine 137
BCNU 128
MDA 125
PEG 123
boron 122
phosphate 122
serine 118
cysteine 109
glutamate 106
ACS 104
ACS 103
acetate 88
iodine 84
retinoic acid 81
TNF 78
Asp 77
MEK 74
nitric oxide 72
ACNU 71
sulfate 70
threonine 70
bromide 66
hydrogen 65
cAMP 64
glutamine 62
alanine 60
tryptophan 58
leucine 57
hyaluronic acid 54
GSH 53
GSH 53
Phe 52
zinc 52
tryptophan 51
tryptophan 50
tryptophan 50
Curcumin 46
His 45
urea 44
Adriamycin 42
hydroxyglutarate 42
galactose 40
ADR 39
salt 39
Gly 39
bis(2-chloroethyl) 36
nitrogen 36
ADP 34
bis(2-chloroethyl) 34
potassium 34
CCNU 34
bis(2-chloroethyl) 34
2-oxoglutarate 34
TOF 33
ASA 33
DTPA 33
NAD 32
copper 32
AMP 32
aspartic acid 31
isocitrate 31
ADP 30
pyrimidine 30
N-acetylaspartate 30
ADP 30
pyrimidine 30
TEM 29
NADPH 29
NADPH 29
GTP 29
aspartic acid 27
aspartic acid 27
aspartic acid 26
DDP 26
acridine 26
silver 25
NAD 25
SDS 25
dUTP 25
THP 24
nicotinamide 24
ethanol 23
MTS 23
H2O2 23
THP 23
ADP-ribose 22
cobalt 22
MIA 22
BSH 22
DMSO 21
PMA 21
N-acetylcysteine 21
manganese 21
VP-16 20
Dexamethasone 20
glycerol 19
Pac 18
Resveratrol 18
TBI 18
fluorine 18
aldehyde 18
PLA 18
Rapamycin 18
methanol 18
CPT-11 17
selenium 17
Metformin 16
Metformin 16
proline 16
Insulin 16
phosphocreatine 16
Vimentin 16
CO2 16
COX 16
XTT 16
CAM 16
pentose 15
PEI 15
pentose 15
GABA 15
GABA 15
GMP 15
silicon 15
formaldehyde 15
pentose 15
pentose 15
valine 15
aldehyde 15
PEI 15
EDTA 14
ANA 14
ANA 14
PMA 14
EDTA 14
COS 14
SOA 14
NH2 14
SN-38 13
Optimal 13
vitamin D 13
NADP 13
GD3 13
ethyl acetate 13
CoA 13
more...