Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0017636 (
glioblastoma
)
18,345
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
EMC6 (endoplasmic reticulum membrane protein complex subunit 6), also known as
transmembrane protein 93
, is a novel positive autophagy regulator. In this report, we evaluated the anti-tumor activity of EMC6 in
glioblastoma
cells in vitro and in vivo. Our data show that overexpression of EMC6 in three
glioblastoma
cell lines (SHG44, U87 and U251) suppresses tumor cell growth by activating autophagy, but fails to induce cell apoptosis. EMC6-mediated autophagy was associated with inactivation of the PIK3CA/AKT/mTOR signaling pathway. Accordingly, EMC6 knockdown in
glioblastoma
cells had the opposite effect; it promoted cell growth. Overexpression of EMC6 also sensitized
glioblastoma
cells to the chemotherapy drug, temozolomide, to further suppress tumor growth. Our data indicate that EMC6-induced autophagy may play a positive role in suppressing the development of
glioblastoma
.
...
PMID:EMC6/TMEM93 suppresses glioblastoma proliferation by modulating autophagy. 2677 97
