Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0017636 (
glioblastoma
)
18,345
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
EGFLAM
as a novel gene biomarker has been reported in some cancers but not
glioblastoma
(
GBM
) yet. To clarify the functional role of
EGFLAM
in
GBM
, we performed this study. Firstly, based on TCGA and Oncomine database,
EGFLAM
expression and clinical significance in
GBM
patients was analyzed. Furthermore, the biological effect of
EGFLAM
in
GBM
cells was determined by qRT-PCR, CCK-8 assay, colony formation assay, wound healing assay, transwell assays and western blot analysis. The databases analysis showed that
EGFLAM
expression was at higher levels in
GBM
patients with poor prognosis. The results indicated that
EGFLAM
silence inhibited the proliferation, migration and invasion of U87 cells, which was regulated through repression of PI3K/AKT pathway. Accordingly, the data from our work shed some light on
EGFLAM
might be a prognostic biomarker and therapeutic target for
GBM
.
...
PMID:EGFLAM correlates with cell proliferation, migration, invasion and poor prognosis in glioblastoma. 3082 11
