Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0017636 (
glioblastoma
)
18,345
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Alpha thalassemia/mental retardation syndrome X-linked
(
ATRX
) is mutated in nearly a third of pediatric
glioblastoma
(
GBM
) patients. We developed an animal model of
ATRX
-deficient
GBM
. Using this model combined with analysis of multiple human glioma genome-wide datasets, we determined that
ATRX
mutation leads to genetic instability, impaired non-homologous end joining, and alternate lengthening of telomeres (ALT).
...
PMID:ATRX mutations and glioblastoma: Impaired DNA damage repair, alternative lengthening of telomeres, and genetic instability. 2731 1
