Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0017636 (
glioblastoma
)
18,345
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
BEX2
has been suggested to promote the tumor growth in breast cancer and
glioblastoma
, while inhibit the proliferation of glioma cells. Thus, the role of
BEX2
in tumor was still in debate. Additionally, the biological functions of
BEX2
in colorectal cancer (CRC) have not yet been clarified. Here, we reported that
BEX2
was overexpressed in advanced CRC from both the GSE14333 database and fresh CRC tissue specimens, and positively correlated with clinical staging. Knockdown of
BEX2
significantly decreased the
in vitro
proliferation of SW620 colorectal cancer cells, suppressed subcutaneous xenograft growth and enhanced the survival of mice with cecal tumors. These effects were mainly mediated by the JNK/c-Jun pathway. Knockdown of
BEX2
inhibited JNK/c-Jun phosphorylation, while
BEX2
overexpression activated JNK/c-Jun phosphorylation. Moreover, the administration of the JNK-specific inhibitor SP600125 to SW620 with
BEX2
overexpression abolished the effect of
BEX2
on SW620 cell proliferation. This study reveals that
BEX2
promotes colorectal cancer cell proliferation via the JNK/c-Jun pathway, suggesting
BEX2
as a potential candidate target for the treatment of CRC.
...
PMID:BEX2 promotes tumor proliferation in colorectal cancer. 2836 93
