Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0017636 (
glioblastoma
)
18,345
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Glioblastoma
(
GBM
) recurrence is attributed to the presence of therapy-resistant
glioblastoma
stem cells (GSCs). Steroid receptor coactivator-1 (SRC-1) acts as an oncogenic regulator in many human tumors. The relationship between SRC-1 and
GBM
has not yet been studied. Herein, we would like to investigate the role of SRC-1 in
GBM
. In this study, we demonstrated that SRC-1 expression is positively correlated with grades of glioma and inversely correlated with glioma patient's prognosis. SRC-1 promotes the proliferation, migration and tumor growth of
GBM
cells. Notably, SRC-1 knockdown suppresses the stemness of
GBM
cells. Mechanistically, lncRNA X-inactive specific transcript (XIST) is regulated by SRC-1 at the post-transcriptional level and mediate the function of SRC-1 in promoting stemness-like properties of
GBM
. SRC-1 can promote the expression of
KLF4
through the XIST/miR-152 axis. Additionally, arenobufagin and bufalin, SRC small molecule inhibitors, can reduce the proliferation and stemness of
GBM
cells. This study reveals SRC-1 promotes the stemness of
GBM
by activating lncRNA XIST/ miR-152/
KLF4
pathway and provides novel markers for diagnosis and therapy of
GBM
.
...
PMID:SRC-1 enhances the stemness of glioblastoma by activating lncRNA XIST/ miR-152/ KLF4 pathway. 3309 Jun 36
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