Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0017636 (
glioblastoma
)
18,345
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
As a hallmark for
glioblastoma
(
GBM
), high heterogeneity causes a variety of phenotypes and therapeutic responses among
GBM
patients, and it contributes to treatment failure. Moreover, hypoxia is a predominant feature of
GBM
and contributes greatly to its phenotype. To analyse the landscape of gene expression and hypoxic characteristics of
GBM
cells and their clinical significance in
GBM
patients, we performed transcriptome analysis of the
GBM
cell line U87-MG and the normal glial cell line HEB under normoxia and hypoxia conditions, with the results of which were analysed using established gene ontology databases as well as The Cancer Genome Atlas and the Cancer Cell Line Encyclopedia. We revealed core signal pathways, including inflammation, angiogenesis and migration, and for the first time mapped the components of the
toll-like receptor 6
pathway in
GBM
cells. Moreover, by investigating the signal pathways involved in homoeostasis, proliferation and adenosine triphosphate metabolism, the critical response of
GBM
to hypoxia was clarified. Experiments with cell lines, patient serum and tissue identified IL1B, CSF3 and TIMP1 as potential plasma markers and VIM, STC1, TGFB1 and HMOX1 as potential biopsy markers for
GBM
. In conclusion, our study provided a comprehensive understanding for signal pathways and hypoxic characteristics of
GBM
and identified new biomarkers for
GBM
patients.
...
PMID:Integrated analysis identified core signal pathways and hypoxic characteristics of human glioblastoma. 3128 8
