Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0017636 (
glioblastoma
)
18,345
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Sterol regulatory element binding proteins (SREBPs) are transcriptional regulators of lipids which promote
glioblastoma
growth. Here, we investigate the effect of inhibiting expression of SREBP target genes in human
glioblastoma
cells. This was achieved by using PF-429242 to inhibit
site-1 protease
(
S1P
), an enzyme required for SREBP activation. Treatment with PF-429242 decreased
glioblastoma
cell viability, induced apoptosis and downregulated steroid, isoprenoid and unsaturated fatty acid biosynthetic pathways. Several pro-inflammatory genes were upregulated. Collectively, these results demonstrate the potential of
S1P
as a target for
glioblastoma
therapy.
...
PMID:Site-1 protease, a novel metabolic target for glioblastoma. 2864 14
