Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0017636 (
glioblastoma
)
18,345
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Previous studies have shown that glucocorticoids can induce the sulfatide-forming enzyme
galactosylceramide sulfotransferase
(GalCer-ST) in cultured
glioblastoma
cells. To investigate whether a similar process occurs in vivo, we administered corticosterone to infant and adult adrenalectomized rats and then assayed brain GalCer-ST activity and sulfatide content. Both measures were unexpectedly decreased rather than increased by hormone treatment, indicating that glucocorticoids may not regulate brain sulfatide biosynthesis in the same manner as observed in clonal cell lines.
...
PMID:Effect of glucocorticoids on galactosylceramide sulfotransferase activity in rat brain. 695 86
