Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0017636 (glioblastoma)
 18,345 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

To evaluate the prevalence of lacunar syndromes due to non ischaemic causes 97 consecutive patients with recent (less than 72 hours) onset of a recognised lacunar syndrome were studied. Investigations showed that nine cases were due to non ischaemic pathologies (four primary intracerebral haemorrhages, one rupture of a mycotic aneurysm, one cerebral abscess, one subdural haematoma, one glioblastoma, one multiple sclerosis). Clinical features did not allow a separation of non ischaemic from ischaemic patients; however, hypertension was significantly more frequent in the latter group, and its positive predictive value in identifying ischaemic patients was 96.6%. Lacunar syndromes due to non ischaemic causes are not rare; since CT scan allowed appropriate treatment in two patients and demonstrated contraindications to antithrombotic therapy in five others, its early use appears warranted in patients with acute lacunar syndromes, particularly if normotensive.
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PMID:Non ischaemic causes of lacunar syndromes: prevalence and clinical findings. 224 71

An attempt is made to utilise so-called absorption analyses in cranial CT for further differentiation of the diagnosis of the various types of space-occupying growths. Characteristic distributions are shown for specific "regions of interest" in meningiomas, glioblastomas and cerebral abscesses before and after contrast medium injections. Clear criteria can be formulated for the differentiation of glioblastoma and cerebral abscess using multivariate discriminance analyses.
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PMID:[Tumor differentiation by multivariate discriminant procedures in CT absorption analyses]. 356 45

Incidentally CNS tumours may simulate acute bacterial or viral meningitis, cerebral abscess, and tuberculous or luetic basal meningitis. 64 cases from the literature are analysed together with 2 personal observations. This form of presentation is found most frequently in high-grade malignancy, i.e. in glioblastoma, medulloblastoma and ependymoma. In the group of benign CNS neoplasms dermoid and epidermoid cysts are most often associated with the meningeal syndrome. The only criterion facilitating a differentiation between acute bacterial meningitis and CNS malignancy is CSF culture. In individual cases an afebrile course, a normal sedimentation rate, and a normal WBC count may help to differentiate. In the presence of basal meningitic or diencephalic symptoms related to a prolonged course discrimination between brain tumour an tuberculous or luetic meningitis may become extremely difficult. In these cases the determination of creatine kinase BB isoenzyme and carcinoembryonic antigen in CSF may overcome the difficulty.
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PMID:[CNS tumors with the clinical picture of meningitis]. 388 30

Early diagnosis of cerebral abscess, which is decisive for the prognosis, is often complicated by the lack of clinical signs. Conventional computed tomography and magnetic resonance imaging cannot always differentiate a cystic or necrotic tumor from an abscess. An abscess is therefore sometimes misdiagnosed as e.g. a glioblastoma or metastasis. Unfortunately, this is sometimes seen at our department and could maybe have been prevented. Diffusion-weighted imaging and apparent diffusion coefficient facilitate differentiation between cerebral tumor and abscess with a sensitivity of 95.2% (76.2-99.9%) and a specificity of 95.7% (78.1-99.9%).
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PMID:[Diffusion-weighted imaging can differentiate cerebral abscesses from tumours of the brain]. 2156 76