Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0017636 (
glioblastoma
)
18,345
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Glioblastomas
(GBMs) are the most aggressive and lethal primary astrocytic tumors in adults, with very poor prognosis. Recurrence in
GBM
is attributed to
glioblastoma
stem-like cells (GSLCs). The behavior of the tumor, including proliferation, progression, invasion, and significant resistance to therapies, is a consequence of the self-renewing properties of the GSLCs, and their high resistance to chemotherapies have been attributed to their capacity to enter quiescence. Thus, targeting GSLCs may constitute one of the possible therapeutic challenges to significantly improve anti-cancer treatment regimens for
GBM
. Ca
2+
signaling is an important regulator of tumorigenesis in
GBM
, and the transition from proliferation to quiescence involves the modification of the kinetics of Ca
2+
influx through store-operated channels due to an increased capacity of the mitochondria of quiescent GSLC to capture Ca
2+
. Therefore, the identification of new therapeutic targets requires the analysis of the calcium-regulated elements at transcriptional levels. In this review, we focus onto the direct regulation of gene expression by KCNIP proteins (
KCNIP1
-4). These proteins constitute the class E of Ca
2+
sensor family with four EF-hand Ca
2+
-binding motifs and control gene transcription directly by binding,
via
a Ca
2+
-dependent mechanism, to specific DNA sites on target genes, called downstream regulatory element (DRE). The presence of putative DRE sites on genes associated with unfavorable outcome for
GBM
patients suggests that KCNIP proteins may contribute to the alteration of the expression of these prognosis genes. Indeed, in
GBM
,
KCNIP2
expression appears to be significantly linked to the overall survival of patients. In this review, we summarize the current knowledge regarding the quiescent GSLCs with respect to Ca
2+
signaling and discuss how Ca
2+
via
KCNIP proteins may affect prognosis genes expression in
GBM
. This original mechanism may constitute the basis of the development of new therapeutic strategies.
...
PMID:Ca
2+
-Dependent Transcriptional Repressors KCNIP and Regulation of Prognosis Genes in Glioblastoma. 3061 19
