Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0017636 (
glioblastoma
)
18,345
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
BACKGROUND
PTPN3
was demonstrated to be involved in the progression of several types of cancers, such as gastric adenocarcinoma, lung cancer, and intrahepatic cholangiocarcinoma. However, its clinical significance in
glioblastoma
(
GBM
) has not been elucidated. MATERIAL AND METHODS We investigated the expression of
PTPN3
in 95 cases of
GBM
with immunohistochemistry and in 8 pairs of fresh GBMs and their adjacent tissues with qualitative polymerase chain reaction. Moreover, the correlation between
PTPN3
and clinicopathological factors was evaluated by chi-square test. The prognostic value of
PTPN3
was investigated with univariate analysis and multivariate analysis. With MTT assay and Transwell assay, the oncogenic functions of
PTPN3
in
GBM
proliferation and invasion were further investigated. RESULTS Expression of
PTPN3
in
GBM
tissues was significantly higher than in their corresponding adjacent tissues. High expression of
PTPN3
was significantly associated with unfavorable prognosis of
GBM
. Moreover, in
GBM
cell lines,
PTPN3
promoted cell proliferation and invasion, and the PTP common inhibitor pervanadate suppressed
GBM
proliferation and invasion. CONCLUSIONS Our experiments show that
PTPN3
is an independent prognostic factor in
GBM
and indicated that postoperative detection of
PTPN3
can be used to identify high-risk patients and guide individual treatment.
...
PMID:High Expression of PTPN3 Predicts Progression and Unfavorable Prognosis of Glioblastoma. 3034 36
