Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0017636 (
glioblastoma
)
18,345
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Cancer stem cells sustain propagation of the deadly primary brain cancer
glioblastoma
.
Glioblastoma
stem cells (GSCs) characterized by a mesenchymal phenotype are aggressive and resistant to therapies and represent a crucial therapeutic target. In this issue of the JCI, Chen et al. show that the intracellular levels of
aldehyde dehydrogenase 1A3
(
ALDH1A3
), known as a functional marker of mesenchymal GSCs, are regulated posttranslationally by ubiquitin-specific protease 9X-mediated (USP9X-mediated) deubiquitination. Increased expression of USP9X stabilizes
ALDH1A3
, enabling GSCs to exhibit mesenchymal traits and the malignant phenotype. Thus, the USP9X-
ALDH1A3
axis may offer a novel therapeutic target in
glioblastoma
.
...
PMID:Deubiquitinating ALDH1A3 key to maintaining the culprit of aggressive brain cancer. 3095
