Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0017636 (
glioblastoma
)
18,345
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Loss of primary cilia is frequently observed in tumour cells, including
glioblastoma
cells, and proposed to benefit tumour growth, but a causal link has not been established. Here, we show that
CCRK
(cell cycle-related kinase) and its substrate ICK (intestinal cell kinase) inhibit ciliogenesis. Depletion of
CCRK
leads to accumulation of ICK at ciliary tips, altered ciliary transport and inhibition of cell cycle re-entry in NIH3T3 fibroblasts. In
glioblastoma
cells with deregulated high levels of
CCRK
, its depletion restores cilia through ICK and an ICK-related kinase MAK, thereby inhibiting
glioblastoma
cell proliferation. These results indicate that inhibition of ciliogenesis might be a mechanism used by cancer cells to provide a growth advantage.
...
PMID:CCRK depletion inhibits glioblastoma cell proliferation in a cilium-dependent manner. 2374 48
