Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0017636 (
glioblastoma
)
18,345
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Coronin-3 (coronin-1C), a homotrimeric F-actin binding protein, has been shown to be important for cell migration and brain morphogenesis. Here, we present for the first time a detailed analysis of the expression pattern of
coronin-3
in human brain tumours and demonstrate that
coronin-3
expression correlates with malignant phenotype in diffuse gliomas. In general, the expression of
coronin-3
varies in different brain tumour entities. However, in diffuse gliomas, the number of
coronin-3
expressing tumour cells correlates with the degree of malignancy. High-grade gliomas, such as anaplastic astrocytomas, anaplastic oligodendrogliomas, anaplastic oligoastrocytomas and glioblastomas, show high numbers of tumour cells positive for
coronin-3
, while diffuse low-grade gliomas, such as diffuse astrocytomas, oligodendrogliomas and oligoastrocytomas, exhibit low numbers of
coronin-3
-positive tumour cells. In order to explore and verify a contribution of
coronin-3
to the malignant phenotype of diffuse gliomas, we employed an efficient shRNA-mediated
coronin-3
knockdown in U373 and A172 human
glioblastoma
cells. Coronin-3 knockdown
glioblastoma
cells exhibited reduced levels of cell proliferation, cell motility and invasion into extracellular matrix compared to control cells. Together, our findings demonstrate evidence for a contribution of
coronin-3
expression in the malignant progression of diffuse gliomas.
...
PMID:Expression of coronin-3 (coronin-1C) in diffuse gliomas is related to malignancy. 1818 30
