Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0017636 (glioblastoma)
 18,345 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 70 year old woman underwent an anterior rightsided temporal lobectomy for a mixed glioblastoma-fibrosarcoma. Six months later, she presented with rightsided zygomatic and maxillary swellings, associated with rightsided ptosis, chemosis, and nerve palsies of the III, IV, VI, and VII cranial nerves. A computerized scan (CT) of the head revealed tumor erosion of the skull base of the right middle fossa with extension into the maxillary sinus. This was confirmed at surgery. Pathologic examination revealed a predominantly small cell anaplastic glioblastoma associated with sarcoma elements, similar to the original intracranial tumor. This case documents a rare and atypical behavior of malignant glial tumors.
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PMID:Gliosarcoma with cranial penetration and extension to the maxillary sinus. 406 29

In a 46 year old patient periorbital pain, miosis and ptosis, i.e. Raeder paratrigeminal neuralgia, were caused by a temporal lobe glioblastoma. This is the fifth case in the literature in which this syndrome was due to a neoplasm.
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PMID:Temporal bone glioblastoma presenting as Raeder paratrigeminal syndrome. 686 39

We present an unusual case of a 41-year-old male patient who presented to the ophthalmology department giving a 3-month history of right sided ptosis, weight loss, diplopia and headache. Clinical examination revealed a right sided relative pupil-sparing third nerve palsy. MRI scan of brain showed thickening of both third nerves. Further investigations revealed a glioblastoma.
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PMID:Gliomatosis presenting as a relative pupil-sparing third nerve palsy in a hypertensive diabetic. 2280 34