Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0017636 (glioblastoma)
 18,345 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Irinotecan (CPT-11) is a chemotherapeutic drug used to treat tumors by acting on malignant cells through inhibition of DNA topoisomerase I and inducing premature apoptosis. Major toxic effects of Irinotecan are myelosuppression and gastrointestinal (GI) toxicity, which limits the dose of administration, particularly severe diarrhea with a delay of onset. However, according to the literature, serious GI side effects are uncommon, comprising 3% of the reported cases. The mechanism of Irinotecan-induced delayed diarrhea is unknown and unpredictable. To our knowledge, this is the first case of colitis associated with Irinotecan administration for temporal glioblastoma documented by biopsies. The histopathologic findings are described and the potential mechanisms inducing such lesions are discussed.
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PMID:Irinotecan-induced colitis. 1586 88

Human cytomegalovirus (hCMV), a member of the Betaherpesvirinae subfamily, was long considered an important pathogen especially in immunocompromised hosts, mainly in post-transplant patients receiving immunosuppressive therapy. Results of many studies from the last decade suggest that cytomegalovirus is a very important pathogen having a greater association with many other diseases. The relationship of hCMV to chronic inflammatory bowel diseases, ulcerative colitis and Crohn's disease, has been long studied but results of the studies have been rather inconclusive. Interestingly, hCMV was found to be more prevalent in lesions of severe ulcerative colitis, in particular ulcerative colitis refractory to immunosuppressive therapy (40-57% in results from clinical studies) than in mild or moderate colitis (up to 5% in most studies). Another group of diseases possibly related to hCMV is tumors. Numerous studies discuss the oncomodulatory role of hCMV in malignant glioblastoma, colorectal adenocarcinomas, prostate cancer and lymphomas. Despite extensive evidence suggesting a possible relationship of hCMV to some tumors, such as successful induction of malignant carcinoma by hCMV latent infection in animal models, hCMV has not been classified as an oncovirus. However, its potential in this respect is apparent.
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PMID:[Cytomegalovirus and its relationship to chronic inflammatory bowel diseases and tumors]. 2457 53