Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0017636 (
glioblastoma
)
18,345
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Glioblastoma
(
GBM
) is an incurable primary brain tumor that is highly resistant to current treatments. Glioma stem-like cells (GSCs) are an aggressive population of glioma cells that not only initiate malignant growth, but also promote therapeutic resistance. Thus, targeting GSCs is critical for improving
GBM
treatment and ensuring complete eradication of the tumor. Here, we show that
NT5DC2
(5'-Nucleotidase Domain Containing 2), a functionally unknown protein, plays a crucial role in GSC tumor initiation via upregulating Fyn expression.
NT5DC2
is preferentially expressed in GSCs relative to the non-stem tumor cells. Knockdown of
NT5DC2
significantly inhibits the GSC tumorsphere formation and cell viability in vitro, and tumorigenesis in vivo, thus, prolonging animal survival. Moreover, disruption of
NT5DC2
in GSCs markedly reduces the expression of Fyn, a Src family proto-oncogene that has been implicated in the regulation of
GBM
progression. Importantly, the expression of
NT5DC2
strongly correlated with increased aggression of human gliomas, but not that of other brain tumors. Taken together, our results uncover the function of
NT5DC2
in GSC maintenance and highlight
NT5DC2
as a promising therapeutic target for
GBM
.
...
PMID:NT5DC2 promotes tumorigenicity of glioma stem-like cells by upregulating fyn. 3097 41
