Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0017536 (giardiasis)
 1,714 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The authors compared cases of acquired immunodeficiency syndrome (AIDS) diagnosed in San Francisco, California, during 1983-1984 with human immuno-deficiency virus (HIV) antibody-negative neighborhood and clinic controls, looking for risk factors for clinical AIDS. They also compared antibody-positive with antibody-negative neighborhood and clinic controls for risk factors for HIV infection. Odds ratios were 52.0 for AIDs and 7.8 for seropositivity for more than 100 sexual partners versus 0-5 partners when antibody-negative neighborhood controls were compared with cases and with antibody-positive neighborhood controls, respectively. Odds ratios were only 2.9 and 3.4 when antibody-negative clinic controls were compared with cases and with antibody-positive clinic controls, respectively. Odds ratios of 4.6-7.3 for rectal receptivity with most or all partners versus none or one partner were statistically significant, independent of the number of partners. Douching before sex was independently associated with odds ratios of 2.2-2.8. There was no evidence for oral-genital, oral-anal, or other sexual transmission of AIDS. In multivariate analysis, independent odds ratios of 2.4-6.0 for prior syphilis and 10.8-27.9 for prior giardiasis were statistically significant or marginally significant in all comparisons. There was a moderate association with nitrite use. No other drugs were consistently associated with clinical AIDS or HIV seropositivity. Odds ratios associated with AIDS and seropositivity were closely comparable except for number of partners.
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PMID:Risk factors for AIDS and HIV seropositivity in homosexual men. 364 28

The number of children Day Care Centers has increased progressively in underdeveloped countries. These Institutions offer conditions that facilitate the transmission of enteric agents. The aim of the present study was to determine the prevalence of Giardiasis in Day Care Centers from San Francisco municipality, Zulia state, Venezuela. A poll was applied to collect personal and clinical data. Fecal samples from 82 children of one or another sex, between 11 months and 6 years old, who normally assist to four Day Care Centers of the municipality mentioned above, were analyzed. The samples were processed by fresh examination, lugol temporal coloration and the formol-ether technique. A percentual analysis was applied for the statistical study. From the 82 processed samples, 37 (45.1%) showed the presence of Giardia lamblia. The clinical symptoms most frequently observed in the study were abdominal pain, diarrhea, weight loss and inappetence. Statistical results did not show a significant difference of this parasitic disease with relationship to sex; however, there is a predominance in children of school age (75%). The result of this work shows a high prevalence of Giardiasis in Day Care Centers of the municipality studied, which suggests that this institutions gather the conditions that facilitate the transmission of this flagellate, and that preventive measures must be put into practice.
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PMID:[Prevalence of giardiasis in day care centers in San Francisco municipality, state of Zulia, Venezuela]. 1252 Sep 96

This study aimed to determine the presence of giardiasis among HIV patients in San Diego, the rate of failure of metronidazole treatment, and factors associated with treatment failure. We used a 7 year retrospective single-center case series of HIV-infected individuals with giardiasis at University of California San Diego Medical Center. Data were analyzed for the changes in the hematological, biochemical, and immunologic results at pre- and at-diagnosis levels. We also compared the changes at the diagnosis level among patients who were treated successfully and those who experienced treatment failure as defined by retreatment with a second course of antibiotics. In 29 Giardia lamblia-infected HIV patients, following diagnosis of G. lamblia, there was a non-significant decrement in cluster of differentiation 4 (CD4), but a statistically significant increase in the number of white blood cell (WBC). Other indices did not differ between pre- and at-diagnosis levels. Twenty patients (69%) were treated with a single course of metronidazole or tinidazole and seven patients (24.1%) were treated with more than one course of metronidazole. These seven patients had statistically significant higher hemoglobin at the time of diagnosis, but further studies are required to confirm if this is a consistent finding and if this can predict failure from primary therapy.
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PMID:Predictors of Failure from Primary Therapy for Giardiasis in San Diego: A Single Institution Retrospective Review. 3156 35