Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0017536 (giardiasis)
 1,714 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A novelty of the present studies is the use of alpha 1-antitrypsin (A-1--AT) as an endogenous marker of enteric protein loss. Enteric clearance of alpha 1-antitrypsin was determined in 10 patients with the symptoms of PLE, and in 6 healthy individuals. Alpha 1-Antitrypsin concentration has been assayed in single, random samples of feces collected from 42 patients and 12 healthy individuals (normal values: 1.31 +/- 0.72 mg/g of feces). Markedly increased enteric clearance and A-1-AT concentrations in single, random samples of feces have been found in patients with enteric lymphangiectasis, Crohn's disease, ulcerative colitis, and constrictive pericarditis, slightly lower in coeliac, chronic diarrhoea, nonspecific hemorrhagic colitis, esophagitis, lambliasis, hypogammaglobulinemia, Wiskott-Aldrich syndrome, Rendu-Osler-Weber syndrome, hepatitis in newborn, and Gilbert's disease. Statistically significant positive clearance has been noted (r = 0.997; p less than .001). A single assay of A-1-AT in feces is simple, repeatable, and sensitive technique in the diagnosis and evaluation of these diseases in which the symptoms of enteric protein loss are seen.
Pol Tyg Lek
PMID:[Alpha 1-antitrypsin as an endogenous marker of protein-losing enteropathies]. 143 95

HLA-DR Antigen expression was shown in the small intestinal mucosa sampled by aspiration biopsy in 12 children infected with Giardia intestinalis. The studies were performed by using three immunohistochemical techniques, with the best results achieved by use of fluorescein- stained avidin biotin system. HLA-DR Antigen expression in Giardiasis was slightly enhanced in the enterocytes of the absorption region; an increased number of HLA-DR positive cells was also found in the lamina propria of the small intestine as compared with controls. This phenomenon is recognized in various inflammations of the small intestinal mucosa.
Patol Pol 1990
PMID:[Expression of HLA-DR antigen in small intestinal mucosa of children infected with Giardia intestinalis]. 215 17

Local humoral response of the intestinal mucosa was determined with secretory IgA levels and secretory component activity in enterocytes and duodenal content of 15 children infected with G. intestinalis. The obtained results were compared to those in 5 children with coeliac disease and 12 children with diarrhoea without lambliasis. Secretory IgA was increased in about 50% of children with lambliasis (in the remaining groups in 25% of children) to the values higher than that in the comparative groups. Secretory component activity was relatively high in the intestinal epithelium. Secretory component activity in the duodenal content was high in about 40% of children independently of the examined group. No correlation between the said variables was noted except positive correlation of secretory IgA levels and secretory component activity in the bile.
Pol Tyg Lek
PMID:[Humoral response of the immunologic secretory system of the small intestine in children infected with Giardia intestinalis]. 221 59

From the presented review of data on clinical pathology of giardiasis the authors conclude that type and variability of pattern and course of the disease are shaped by several factors. On one hand they are influenced by genetically distinct character of a given Giardia isolate, its pathogenicity, ability to colonize small intestine and releasing of secretory-excretory products; on the other hand the clinical variability reflects immune response of the host, development and intensity of pathomorphology in the intestine mucosa, secondary secretory disturbances in gastric mucosa and coexistence of pathogenic bacterial flora in small intestine. Application of not only the serological tests (ELISA, IF) to detect antibodies against Giardia but also use of tests detecting Giardia GSA65 co-proantigen and of analysis of parasite DNA represent significant progress in diagnosing Giardia invasion. The modern tests do not negate the need of performing morphological Giardia analysis which continues to represent a basic test in giardiasis.
Pol Merkur Lekarski 1997 Dec
PMID:[Clinical pathology and diagnostic aspects of giardiasis]. 952 69

The evaluation of eosinophil cationic protein (ECP) concentration--one of late allergy reaction markers was performed in serum of children with food allergy and children with food allergy and H. pylori or Giardia lamblia infection of the gastrointestinal tract. The ECP values were referred to the characteristics of histopathological changes in gastric mucosa and to the values of cytokines (IL-4, IL-5, IL-8) determined in biopsy specimens of gastric mucosa from these patients. The studies indicate that the exclusive evaluation of ECP concentration in serum does not reflect unequivocally the severity of pathological changes of gastric mucosa in children with food allergy.
Pol Merkur Lekarski 2003 Jan
PMID:[Eosinophil cationic protein in serum of children with food allergy]. 1271 20

Giardiasis was detected in 53.5% of dogs examined by FASTest Giardia Strip for use in dogs. Using the ProSpecT Giardia EZ Microplate Assay 52.2% of these results was confirmed. Cysts of Giardia spp. were found only in 6.5% of samples of feces examined by flotation or decantation techniques. The examinations confirmed problems with coproscopic diagnosis of giardiasis in dogs. They confirmed the greater usefulness of FASTest Giardia Strip for immunodiagnostic of giardiasis in carnivores.
Pol J Vet Sci 2005
PMID:Comparison of some serological methods and coproscopic examinations for diagnosis of Giardia spp. invasion in dogs. 1598 33