Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0017536 (giardiasis)
 1,714 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

There is controversy both in regard to the severity of small bowel mucosal damage attributable to giardiasis and to the causal relationship of these changes to the associated diarrhoea. In this series of 17 consecutive patients with giardiasis, small bowel histology and diarrhoea were independently assessed and compared. Disaccharidase assays were performed in 16 of these patients and a repeat biopsy obtained in seven cases. On histological examination the villous architecture varied from normal to sub-total villous atrophy. When these changes were compared with the severity of diarrhoea, a direct correlation was obtained, the more severe symptoms being associated with the more severe villous changes. Repeat biopsy after treatment demonstrated improvement in the histology which correlated with improvement in diarrhoea. Lactase activity was low in all patients with moderate or severe diarrhoea as well as in some patients with mild diarrhoea, two of whom had normal histology. This series demonstrates the occurrence of a spectrum of mucosal changes in giardiasis and supports the concept that these changes mediate the diarrhoea associated with this gut parasite.
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PMID:Histopathology in giardiasis: a correlation with diarrhoea. 10 99

Under the aspect of systemic diseases and their manifestation in the gut the following conclusions can be drawn: 1. The skin is the mirror of the intestinal tract; not only in primary gastroenterological disorders one should look for dermatological complications, but should also think in chronic skin lesions of concomitant intestinal alterations. 2. In all patients with collagen diseases a gastrointestinal involvement is very common. 3. In all endocrine disorders except in hypothyroidism diarrhea is a very common finding. 4. Infiltrations of gastrointestinal tract can be demonstrated in many cases by gastric, small bowel or rectal biopsy. 5. In all forms of dysgammaglobulinemia giardiasis is very common. 6. In right heart failure protein-losing enteropathy should be considered, in left ventricular insufficiency bowel ischemia.
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PMID:[Manifestations of systemic diseases in the gastrointestinal tract]. 96 97

Intraepithelial lymphocyte counts were evaluated in 131 jejunal mucosal biopsies taken from children with a small intestinal enteropathy arising from a variety of causes including coeliac disease, (untreated, after gluten withdrawal, and during subsequent challenge), giardiasis, cow's milk protein intolerance, and 'intractable diarrhoea'. The counts were compared with those from the biopsies of children referred for investigation but in whom no gastrointestinal disease was demonstrated and from healthy siblings of children with coeliac disease, investigated during a family study. Children with coeliac disease showed a raised count which fell after gluten withdrawal as has been demonstrated by others in adults. Lymphocytic infiltration of the epithelium increased rapidly during gluten challenge in such children, while no change was seen in those children proven ultimately not to have coeliac disease by the usually recognized criteria. In other enteropathies the range of counts was wide, overlapping with both normal and coeliac groups and indicating the nonspecificity of lymphocytic infiltration of the gut epithelium. The findings are discussed in relation to their significance and to further avenues of investigation to determine their possible diagnostic value in confirming the diagnosis of coeliac disease during gluten challenge.
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PMID:Evaluation of the intraepithelial lymphocyte count in the jejunum in childhood enteropathies. 97 98

The authors recall the main etiopathogenetic, immunological and clinical features of Giardiasis; they report on a patient suffering from intestinal Giardiasis associated with immunoglobulin deficiency and nodular lymphatic hyperplasia of the gut. They report the results of medical therapy.
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PMID:[A case of intestinal giardiasis associated with immunoglobulin deficiency and intestinal lymph node hyperplasia]. 169 26

Gastrointestinal immune events in giardiasis are important in controlling infection. In this study, Peyer's patch lymphocytes from mice infected with Giardia muris developed specific, proliferative responses to G. muris antigen. This proliferation correlated with clearance of infection. Further understanding of the gut immune response will be helpful in developing immunoprophylactic strategies in the control of giardiasis.
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PMID:Lymphocyte proliferation in Peyer's patches of Giardia muris-infected mice. 169 8

The responses of intestinal T-cell subsets and immunoglobulin containing cells were assessed during the course of experimental Giardia lamblia infection in inbred NMRI mice. Quantitation of T-cell subsets in intraepithelium (IEL) and lamina propria (LPL) revealed increased influx of Lyt 2.2+ (suppressor/cytotoxic) T cells and Thy 1.2+ T cells during the establishment (3-5 days post-inoculation) and peak (9-11 days post-inoculation) phases of infection. The influx of these cells reduced as the parasite load declined. In contrast, no significant change was noticed in lamina propria and intraepithelial L3 T4+ (helper/inducer) T cells during the establishment or acute phases. However, these cells increased significantly in the decline phase (17-21 days post-inoculation) of infection. The lamina propria IgA-containing cells significantly declined during the establishment and acute phases of infection, and increased significantly as the parasite load in the jejunum declined. Helper/inducer ratios of 0.4 for IEL and 2.0 for LPL accompanied the decline of G. lamblia trophozoites in the gut. Our data thus suggest that induction of helper/inducer T cells during the decline phase of infection concomitant with an increase in lamina propria IgA-containing cells resulted in elimination of G. lamblia trophozoites from the gut.
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PMID:Kinetics of intraepithelium and lamina propria lymphocyte responses during Giardia lamblia infection in mice. 183 23

Sixty children with chronic diarrhoea, age ranging from 9 months to 3 years and 15 normal healthy children of same age group, all belonging to the low socio-economic families formed the basis of this study. Fifty-six out of these 60 children were undernourished and were marasmic. Stool examination showed enteropathogenic E. coli in 24 (40 per cent), Ascaria lumbricoides in 12 (20 per cent) and Giardia lamblia in 6 (10 per cent). Coeliac disease was detected in 2 (3 per cent) and combined IgA-IgG deficiencies were found in one case (2 per cent). No cause could be found in 15 (25 per cent) cases. Multiple aetiological factors were found in 7 (12 per cent) cases. Stool IgA levels were significantly elevated in the patients than in the controls and more so in the patients with giardiasis and also in patients with coeliac disease. Serum IgA levels were remarkably raised in the patients with diarrhoea due to enteropathogenic E. coli, indicating probable spilling of gut-associated IgA into the circulation. No IgA was detected in the stool of a dysgammaglobulimic patient, who had both serum IgA and IgG deficiencies.
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PMID:Raised stool and serum IgA levels in undernourished infants with chronic diarrhoea and associated parasitic infestations. 235 7

Stool specimens, obtained from 1813 schoolchildren from communal lands, commercial farms and urban areas in Zimbabwe, were examined for helminth and protozoan parasites. The findings were collated with anthropometric data on the same children to investigate the relationship between intestinal parasitism and nutritional status. Protozoan infections were common with Giardia lamblia being identified in 17.4% of children. There was a strong association between giardial infection and undernutrition, wasting and stunting in these children. There was no evidence of an association between helminth infection and undernutrition. In view of the known impairment of absorption from the gut in giardiasis, it is suggested that giardial infection may be an important factor contributing to the low nutritional status of many primary schoolchildren in Zimbabwe.
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PMID:Giardiasis and the nutritional status of Zimbabwean schoolchildren. 242 98

Twenty patients (18 M, 2 F; age 16-32 yrs) with symptomatic giardiasis were treated with tinidazole: ten each with a dose of 150 mg twice daily for 7 days, and a single dose of 2 g (50 mg/kg). Stool examination by formalin-ether concentration method was carried out before and one month after treatment. Cure was defined as absence of G lamblia in the stools. Fecal fat excretion (100 g load) and D-xylose absorption (5 g load) were measured before treatment and, if abnormal, repeated one month after treatment. Gut transit time was measured before and one month after treatment by giving radio-opaque beads orally and following their progress fluoroscopically to complete elimination. Parasitologically, all 20 patients were cured. Clinically, there was marked to complete relief of symptoms. Concomitantly, there was significant (p less than 0.01) reduction in fecal fat excretion, improvement in D-xylose absorption, and increase in gut transit time.
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PMID:Efficacy of tinidazole (Fasigyn) in giardiasis by parasitologic, biochemical, and gut transit studies. 270 40

Following Giardia lamblia infection in immune intact NMRI mice, increased numbers of IgM-containing cells and decreased numbers of IgA containing cells were noticed in the lamina propria during the establishment (3-5 days) and acute (9-11 days) phases of infection. The decline in IgM-containing cells during the clearance phase of infection (17-21 days post-infection) was accompanied by an increase in IgA and IgG-containing cells. Our data suggest that the locally synthesized antibodies, especially of the IgA class, play a significant immunodulatory role in the clearance of G. lamblia infection from the gut. Mice immunosuppressed using rabbit anti-mouse lymphocyte serum or dexamethasone had significantly reduced numbers of IgA and IgG-containing cells during all phases of infection and higher parasite loads in their jejunum. It appears that one of the reasons for increased severity and chronicity of G. lamblia infection is the decrease in immunoglobulin-containing cells in the gut.
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PMID:Sequential changes of lamina propria immunoglobulin-containing cells in immune intact and immunosuppressed mice infected with Giardia lamblia. 279 5


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