Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0017536 (giardiasis)
 1,714 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Empirical antimicrobial therapy is indicated in patients with diarrhoea who have high fever and systemic toxicity, dysenteric disease, or travellers' diarrhoea. Antimicrobials are essential for those with severe shigellosis and amoebiasis. They are useful or possibly useful for other forms of diarrhoeal disease including amoebiasis (milder forms), campylobacteriosis, cholera, giardiasis, shigellosis, and diarrhoea due to a variety of other laboratory-defined bacterial enteropathogens. Furazolidone is useful in infantile giardiasis and mildly effective in other forms of bacterial diarrhoea. Trimethoprim/sulphamethoxazole is effective against Shigella spp. in ost parts of the world. Erythromycin is considered the treatment of choice for campylobacteriosis. For adults, the quinolone antimicrobials represent the most useful class of drugs for bacterial enteropathogens. Several dilemmas currently exist in the area. They include the lack of drugs for the therapy of trimethoprim-resistant shigellosis in children, overuse of antimicrobials in the developing world, and the potential for post-treatment prolongation of intestinal excretion of non-typhoid salmonellae. Antimicrobial chemoprophylaxis can be used in the rare person from an industrialized area during brief travels to a tropical region who has a serious underlying medical problem, cannot exercise care in what is eaten and drunk, and will have the purpose of the trip put at jeopardy should any illness develop (even that rendered short-term by effective therapy). For most people, therapy of illness is preferred to prophylaxis.
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PMID:Diarrhoeal disease: current concepts and future challenges. Antimicrobial therapy and prophylaxis. 810 47

In this study, clinical, parasitological, macroscopical, histopathological and immunohistochemical examinations were performed on 19 kids and 11 lambs (30 animals) with neonatal diarrhoea to detect the presence of Coronavirus, Cryptosporidium parvum and Giardia intestinalis. Clinically, severe dehydration, yellowish-green to brown coloured diarrhoea and death were observed. Mortality rates were 10-30% in the examined flocks. The most common agent was C. parvum diagnosed in 20 animals as a single causative agent, whereas G. intestinalis was found in 5 of 30 animals. These two protozoa were detected together in 4 animals upon faeces examination. Fifteen of 24 cases of C. parvum and 3 of 11 cases of G. intestinalis were also confirmed histopathologically. Following immunohistochemical examination, all cryptosporidiosis cases were confirmed by positive immunostaining of intestinal sections. Two additional Giardiosis cases with negative results upon parasitological and histopathological examinations were diagnosed by means of immunohistochemical examination. Coronavirus was detected immunohistochemically in one kid with neonatal enteritis. Following diagnosis, herds were treated with Trimethoprim + Sulfodoxine and multivitamin complexes. Intravenous and intramuscular administrations of these drugs were effective for both treatment and prevention of neonatal diarrhoea in lambs and kids.
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PMID:Observations and immunohistochemical detection of Coronavirus, Cryptosporidium parvum and Giardia intestinalis in neonatal diarrhoea in lambs and kids. 1688 22