Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0017536 (giardiasis)
 1,714 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A new metronidazole derivative, Tiberal (Ro-07-0207, Roche Laboratories), was evaluated in 22 children with Giardia lamblia infection. Seven patients received an oral dose of 1 g twice daily for one day; the remaining 15 patients received a single dose of 50 mg/kg. Parasitological cure was noted in all 22 patients. Significant side effects were observed only in those children who received the drug at the higher dosage regime. The present study also confirms the findings of other authors that a mucosal imprint method is more reliable than examination of stools, duodenal juice or jejunal biopsy material for the detection of G. lamblia infection.
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PMID:Single dose treatment with Tiberal of Giardia lamblia infection in children. 36 19

In 15 months of the years 1979-1980, 158 patients with giardiasis and 69 patients with intestinal amebiasis were diagnosed and treated in the outpatient department of the Swiss Tropical Institute. Repeated examination of merthiolate-iodine-formol-fixed stools was the method of choice for detecting intestinal protozoa. Parasitological investigation of duodenal fluid (Enterotest) was less effective. Fewer than 30% of the cases were symptomatic, usually mentioning diarrhea (73-85%) or abdominal discomfort (20-44%). Treatment was by ornidazole single dose (2 g in adults; 40 mg/kg in children) for asymptomatic cases and a five-day treatment schedule (2 X 500 mg/day in adults, 20 mg/day in children) for symptomatic cases. In amebiasis a luminal amebicide (diloxanide furoate) was prescribed in all instances after the first stool examination. Parasitological cure rates were excellent (95%) in all cases of giardiasis but only 59 and 65% respectively in cases of asymptomatic and symptomatic amebiasis. Drug tolerance was excellent. Ornidazole is the drug of choice for all forms of giardiasis, even in a single dose. As a luminal amebicide, however, its efficacy is not superior to other nitroimidazole derivatives.
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PMID:[Clinical and therapeutic study of a group of 217 patients with intestinal giardiasis and amebiasis]. 627 72

Ornidazole or tinidazole as a single dose of 1.5 g was given to 100 patients with symptomatic giardiasis. Parasites disappeared from the feces of all patients, usually within 2 or 3 days, and symptoms subsided in 98 cases, usually within 5 days. During an 8-wk follow-up, parasites reappeared in 10 patients, 5 after each drug, between 1 and 7 wk after treatment. The relapses were usually symptomatic, and the probability that they were reinfections was negligible. Ornidazole appeared in serum more rapidly than tinidazole, and the mean elimination half-lives were 10.9 and 11.1 h, respectively. Subjective side effects were equally common after both nitroimidazoles; dizziness was associated with rapid initial absorption. We found no correlation between drug absorption or elimination and therapeutic efficacy. Both drugs are recommendable as a single oral dose of 1.5 g in giardiasis.
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PMID:Treatment of giardiasis: comparative evaluation of ornidazole and tinidazole as a single oral dose. 708 17

One hundred and twenty four children with symptomatic and parasitologically confirmed giardiasis were treated in a comparative trial. The dosage of antigiardia drug was adjusted to the body surface area of the patients from the adult basic dosage as 100 mg of quinacrine t.i.d. for 5 days, 200 mg of metronidazole t.i.d. for 7 days, 2 gm of metronidazole once, 2 gm of tinidazole once or 2 gm of ornidazole once. They were hospitalized for follow-up for 30 days. The parasitological follow-up consisted of daily examination of stool specimens. Reinfections were unlikely. The rates of success were: a 5-day course of quinacrine, cured all of them, 20 patients; a 7-day course of metronidazole, 12 of 20; metronidazole, single dose, 11 of 21; tinidazole, single dose, 18 of 21; ornidazole, single dose, 21 of 22; placebo, none of 20. After a single dose, 5 patients had transient elevation of transaminases, one patient in each of metronidazole and tinidazole group 3 patients in ornidazole group. A 5-day course of quinacrine gave excellent result but the drug is not widely marketed. Ornidazole or tinidazole were more effective, both of them were recommended as a drug of choice as single dose therapy, however transient increase of transaminases may occur in some cases.
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PMID:Treatment of giardiasis in children with quinacrine, metronidazole, tinidazole and ornidazole. 743 79

Ornidazole (Tiberal La Roche) was used in 50 persons infected with Giardia intestinalis in the doses of 500 mg twice a day during 5 days. Examinations were performed after 7-10 days, having been repeated one month and 3 months later. A positive results were achieved after one month in 46 cases (92%) and after 3 months in 45 cases (90%). Tiberal is thought to be effective drug in the treatment of Giardiasis, causing no side effect apart from headache and nausea occurring sporadically.
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PMID:[Observations of the efficacy of ornidazole (Tiberal La Roche) in treatment of giardiasis]. 802 8

Ornidazole is a commonly prescribed antiparasitic drug for parasitic infestations, including amoebiasis, giardiasis and Trichomonas vaginalis. Several cases of antibiotic-induced autoimmune hepatitis (AIH) or AIH-like syndrome have been reported recently. In this report, we describe a 35-year-old woman with two relapses of AIH induced by ornidazole prescribed for diarrhoea and vaginal infection.
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PMID:Ornidazole-induced autoimmune hepatitis. 1143 5

The formalin ester-enrichment test for giardiasis was used to examine 742 children aged under 14 years at children's clinical hospitals in the town of Perm in February to October 2000. All the children had symptoms of gastrointestinal lesions. Giardiasis was detected in 26.4% of the children; including 21% among 200 children aged 0-2 years, 26.6% among 297 children aged 3-6 years, 30.6% among 245 children aged 7-14 years. Various background abnormalities were revealed in 158 children, including 62 and 68 children aged 3-6 and 7-17 years, respectively. The background abnormality makes a clinical diagnosis of giardiasis difficult and lowers the efficiency of specific treatment. Macmiror and tiberal are the most effective in treating giardiasis in all age-group children. Tiberal is preferable for treating children without background abnormalities. Specific treatment for giardiasis should be combined with the use of probiotics and enzymes.
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PMID:[Treatment of giardia in children under current conditions: efficacy and choice of specific drug]. 1229 65