Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0017536 (giardiasis)
 1,714 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Decline in the specific activities of intestinal cytosolic glucose-6-phosphate dehydrogenase (G6PD) and isocitrate dehydrogenase (ICDH); brush border glucoamylase, and isomaltase; and basolateral (Na+, K+)-ATPase activities were observed during the establishment, acute phase and decline phase of infection in Giardia lamblia-infected mice. The degree of decline in the activities of various enzymes correlated well with the number of trophozoites counted in the jejunum. There appeared to be a gradual recovery of enzymatic activities during the decline phase of infection, when the number of trophozoites also declined. The decline in activities of these enzymes may contribute to malabsorption of nutrients during giardiasis.
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PMID:Alterations in enzymatic activities of the intestinal mucosa during the course of Giardia lamblia infection in mice. 1667 Jul 64

The tricyclic antidepressant drug chlorimipramine, some of its congeners, and its mammalian metabolites inhibited the growth in vitro of the human intestinal pathogen Giardia lamblia. The inhibitory action may reside in their ability to inhibit the membrane-associated ATPase characteristic of eukaryotes. Synthesis of other compounds of the tricyclic class may produce drugs of potential therapeutic use in the treatment of giardiasis and possibly other protozoal diseases.
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PMID:Antidepressant drugs suppress growth of the human pathogenic protozoan Giardia lamblia. 398 67

Hypokalemic myopathy may occur in several infections. We report a case of severe and transient myopathy secondary to hypokalemia induced by chronic intestinal infection with Giardia lamblia in a patient with common variable hypogammaglobulinemia. Hypokalemic myopathy is documented by serum enzymes, electromyography (reduction in the number of voluntarily activated motor unit action potentials and an increase in polyphasic motor unit action potentials, and pathological changes (hematoxylin-eosin, ATPase staining). The case reported involves hypokalemic myopathy induced by giardiasis in a patient with primary immunodeficiency; the histopathological changes observed in a skin/muscle biopsy from this patient are described for the first time.
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PMID:Giardiasis as a cause of hypokalemic myopathy in congenital immunodeficiency. 885 67