Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0017536 (giardiasis)
 1,714 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Decline in the specific activities of intestinal cytosolic glucose-6-phosphate dehydrogenase (G6PD) and isocitrate dehydrogenase (ICDH); brush border glucoamylase, and isomaltase; and basolateral (Na+, K+)-ATPase activities were observed during the establishment, acute phase and decline phase of infection in Giardia lamblia-infected mice. The degree of decline in the activities of various enzymes correlated well with the number of trophozoites counted in the jejunum. There appeared to be a gradual recovery of enzymatic activities during the decline phase of infection, when the number of trophozoites also declined. The decline in activities of these enzymes may contribute to malabsorption of nutrients during giardiasis.
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PMID:Alterations in enzymatic activities of the intestinal mucosa during the course of Giardia lamblia infection in mice. 1667 Jul 64

Electrophoretic mobility patterns of six enzymes, viz. alkaline phosphatase E.C. 3.1.3.1., acid phosphatase E.C. 3.1.3.2., malic enzyme E.C. 1.1.1.40., phosphoglucomutase E.C. 2.7.5.1., isocitrate dehydrogenase E.C. 1.1.1.42., glucose-6-phosphate dehydrogenase E.C. 1.1.1.49 of two axenically cultured human Giardia lamblia isolated from India (PD-1 and PD-2) and one strain from Portland, Oregon, USA (P-1) were compared using polyacrylamide gel electrophoresis (PAGE). Based on the difference in the mobility patterns of the enzymes phosphoglucomutase, isocitrate dehydrogenase and malic enzyme, the PD-1 and PD-2 isolates appeared to be quite different from P-1. In the present study, the isocitrate dehydrogenase and alkaline phosphatase enzymes were used for the first time for differentiation of Giardia isolates. In the case of PD-1, two alkaline phosphatase bands could be seen whereas only one band was observed in PD-2 and P-1. Thus, the three strains could be grouped into three different zymodemes. These findings reveal the significant heterogeneity in G. lamblia isolates both from widely separated areas and within a single region. Heterogeneity among G. lamblia strains may explain the variable clinical manifestations, host response and treatment efficacy characteristic of human giardiasis.
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PMID:Identification of heterogeneity in human isolates of Giardia lamblia by isoenzyme studies. 183 Jul 42