Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0017536 (giardiasis)
 1,714 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Joint involvement in giardiasis is reported in children and young persons only with one exception. We present two cases of adult patients (a thirty-year-old woman, 26-year-old man) who developed a slowly aggravating arthritis in PIP-joints, ankles and knees with a tendency to chronification or relapse. Giardiasis was diagnosed by examination of feces. Treatment with ornidazole was effective in arthritic and gastrointestinaly symptoms. The patients had neither ESR elevation nor any other signs of inflammatory processes. The arthritis factor was negative. HLA-typing showed no phenotypes associated with arthritides.
 ...
PMID:[Arthritis in lambliasis intestinalis (giardiasis) in the adult]. 174 71

A study has been performed on 467 cases of differents parasitic diseases and ABO blood groups. With classical statistical methods, we did not find any correlation, but with a large number of variables, we used the factorial analysis, and we obtained maps with relationship O-hookworm and strongloidiasis. A-giardiasis, B-Entamoeba coli. But AB group seems to be far from all parasitosis. Besides, blood group and severity of diseases seem not to be related. With HLA groups, a study by microlymphocytotoxicity on 36 West-African (Sarakole people) showed that HLA B5 is predominant in cases of schistosomiasis.
 ...
PMID:Study of relationship of ABO and Rh blood group, and HLA antigens with parasitic diseases. 249 87

Biopsy of the liver revealed granulomas in portal tracts and cholangitis in a woman with chronic diarrhea, weight loss, fever, hypoalbuminemia, and anemia attributed to giardiasis. Eradication of Giardia resulted in rapid improvement of symptoms and resolution of histologic changes on a second biopsy of the liver after 3 mo. The patient had serum immunoglobulin levels that were either normal (IgG, IgM) or elevated (IgA), detectable levels in serum of anti-Giardia antibody, and an HLA phenotype (B12, B27) known to be associated with prolonged giardiasis.
 ...
PMID:Granulomatous hepatitis and cholangitis associated with giardiasis. 708 26

Two patients had IgA deficiency, giardiasis, and the HLA-B8 antigen. The family of patient 1 included members with juvenile-onset diabetes mellitus, adrenal insufficiency, pernicious anemia, and hypothyroidism, a combination of unusual diseases that has been reported previously to occur as a syndrome with IgA deficiency and the HLA-B8 antigen. This coincidence makes it likely that these two patients and the one family previously described have a common pathogenic base, the inheritance of an abnormal immune-response gene that is acquired with the HLA-B8 antigen as a result of genetic dysequilibrium.
 ...
PMID:Selective IgA deficiency and the HLA-B8 antigen. Report of two cases with familial data. 721 94

Fifty patients suffering from persistent giardiasis and 257 healthy persons from Uzbekistan were examined. HLA-typing was carried out by the Terasaki microlymphocytotoxicity technique. The patients with persistent giardiasis were characterized as a significant prevalence of HLA-B5, HLA-B14, HLA-DR3, DR4, DR7 and haplotypes HLA-A9-B5 and A1-B5. These haplotypes and HLA antigens can be considered as markers of predisposition to persistent giardiasis.
 ...
PMID:[The characteristics of HLA antigen distribution among patients with persistent lambliasis]. 793 80

A total of 455 children were chosen randomly and surveyed for giardiasis by stool examination using several techniques. A case control study design was adopted where 91 cases of giardiasis (symptomatic and asymptomatic) and 101 children giardiasis free were examined. ABO blood groups and HLA typing were investigated. It was concluded that blood group A was more susceptible to giardiasis especially asymptomatic form, while blood group B was less susceptible to giardiasis. On the other hand, there was no association between AB or O and giardiasis. But, there was a strong association between HLA A10, A11, B5, B7 and B17 phenotypes and symptomatic giardiasis and an association as well between HLA B7, B17, Bw14 and Bw40 and asymptomatic giardiasis.
 ...
PMID:The relation between ABO blood groups, HLA typing and giardiasis in children. 807 60

Wide variation has been observed in the natural history of human and murine giardiasis, which could be due to factors associated with the parasite or with the host. In humans, prolonged infections with Giardia duodenalis have been associated with hypogammaglobulinemia, protein-calorie malnutrition, and prior gastrectomy. The duration of infection or severity of symptoms may also be influenced by the humoral immune response and by other factors such as ABO blood group and HLA antigen type. Elimination of Giardia muris is impaired in hypothymic mice, B-cell-deficient mice expressing the xid gene, and in mice deficient in mast cells. Prolonged infections also occur following depletion of helper/inducer T cells and suppression of antibody production with antisera to IgM. However, quantitative or qualitative defects in immune function do not appear to account for prolonged cyst excretion in C3H/He, C3H/HeJ, and A/J mice. The defect in these strains is influenced by several genes and may involve intermediate or late stages of macrophage activation leading to impaired elimination of the parasite.
 ...
PMID:Genetic studies of human and murine giardiasis. 845 66

Celiac disease (CD) is an inflammatory disease of the small intestine. A complete management and differential diagnosis of such disease includes food intolerances, intestinal infections, and irritable bowel syndrome. We describe an 8-years-old adoptive girl from Congo with negative medical history. Patient followed for recurrent abdominal pain and diarrhea associated to Giardia infection, unresponsive to antiparasitic therapy. Persistence of symptoms despite antiparasitic therapy, prompted us to perform: 1- Blood screening of Celiac disease, which was negative; 2- Genetic evaluation of celiac disease, which revealed the presence of HLA-DQ2 heterodimer; and 3- Esophagogastroduodenoscopy, which showed duodenal villous atrophy and crypt hyperplasia, associated with Helicobacter Pylori infection. The child was treated in accordance with international recommendations using a Gluten-free diet and specific antibiotics, which lead to the resolution of the symptoms. Our patient's clinical history seems peculiar, considering that, recurrent Giardiasis may mimic the symptoms of Celiac disease and may simulate clinical and histological picture of active Celiac disease. Early diagnosis may help prevent the complications of untreated celiac disease.
...
PMID:Celiac Disease in an Adoptive Child with Recurrent Giardia Infection. 2630 40

Villous atrophy in absence of coeliac disease (CD)-specific antibodies represents a diagnostic dilemma. We report a case of a woman with anaemia, weight loss and diarrhoea with an initial diagnosis of seronegative CD and a histological documented villous atrophy who did not improve on gluten-free diet due to the concomitant presence of common variable immunodeficiency (CVID) and Giardia lamblia infection. This case report confirms that CD diagnosis in CVID patients is difficult; the combination of anti-endomysial antibodies (EmA-IgA), anti-tissue transglutaminase antibodies (tTG-IgAb) antibodies and total IgA is obligatory in basic diagnostic of CD but in CVID are negative. Furthermore, the typical histological aspects of the intestinal mucosa in CVID (absence of plasma cells and switch to the IgD immunoglobulins), cannot rule out a concomitant CD diagnosis. HLA typing in this setting has a low positive predictive value but should be considered. Histological response to a gluten-free diet on repeat biopsy and the concomitant treatment of other causes of villous atrophy leads to a definite diagnosis of CD.
 ...
PMID:A difficult diagnosis of coeliac disease: Repeat duodenal histology increases diagnostic yield in patients with concomitant causes of villous atrophy. 2932 51