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Query: UMLS:C0017536 (giardiasis)
 1,714 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We have presented a case of atopic dermatitis associated with Giardia lamblia infection, which has not been previously described. Review of the world literature shows an association between giardiasis and urticaria. Other allergic phenomena, such as angioedema and possibly arthropathy, also might be associated with this infection. When confronted with these clinical problems, giardiasis should be included in the differential diagnosis. As these complications respond to specific therapy, identification of this organism as its cause can be particularly rewarding.
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PMID:Dermatologic manifestations of giardiasis. 149

One hundred children were entered into a randomized study to compare the efficacy and safety of furazolidone and metronidazole when given in liquid suspension for treatment of giardiasis. The study was conducted between May 1985 and February 1986. Dosages were calculated on the basis of body weight, and treatment lasted 10 days. Clinical diagnosis of giardiasis was confirmed by the presence of Giardia cysts in stools. Children were excluded from the study if stool culture was positive for pathogenic bacteria. Eighteen of the 100 children were withdrawn from the study because of noncompliance with the protocol. Of the 82 remaining patients, 37 received furazolidone and 45 metronidazole. No statistically significant differences in efficacy between treatments were found. With the exception of one case of urticaria, which occurred in a patient who received metronidazole, both drugs were well tolerated. In this study, furazolidone and metronidazole were equally safe and effective in treating children with giardiasis.
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PMID:Furazolidone and metronidazole for treatment of giardiasis in children. 269 46

Travelers' diarrhea afflicts some 250 million people yearly. A number of etiologic agents have been identified, including bacteria, viruses, and parasites. Giardia lamblia is one of the pathogens clearly associated with this syndrome. Typical symptoms of giardiasis that include abdominal bloating and cramps are well known, whereas urticaria has rarely been associated with this illness. An American tourist developed acute giardiasis accompanied by urticaria and high fever. No other pathogens were identified, and response to metronidazole therapy was prompt. Giardiasis should be included in the differential diagnosis of acute urticaria and fever in the traveler.
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PMID:Fever and urticaria in acute giardiasis. 270 46

About three clinics cases, the author points out the presence of urticaria symptoms associated with giardiasis disease, and necessity of the treatment of such parasitosis, after parasitological investigation of motions.
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PMID:[Skin manifestations of giardiasis. Some clinical cases]. 721 67

The aim of the study was to test new treatment protocols for giardiasis, which are less toxic, cheaper, and easier to use than the conventional treatment. 48 children who had been diagnosed as having giardiasis in a health-screening program involving 2 schools, were randomized to receive four different treatment protocols. The children were split into 4 treatment groups: I, mebendazole 100 mg t.i.d. for 1 day; II, mebendazole 100 mg t.i.d. for 7 days; III, metronidazole 15 mg/kg as one dose for 7 days; and IV, ornidazole 40 mg/kg as a single dose. The results were evaluated by microscopic examination of stools. The responses to the treatments revealed that the effectiveness of ornidazole was 100%, metronidazole 92.9%, mebendazole for 7 days 58.3%, and mebendazole for 1 day 41.7%. Minor side-effects were seen in only 3 children receiving ornidazole: 1 had urticaria, while the other 2 suffered from vertigo and nausea. The results of this study show that ornidazole as a single dose can be used as an alternative protocol for treating giardiasis. Further studies should be done to determine the safest effective total single dose.
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PMID:Alternative treatment protocols in giardiasis: a pilot study. 895 80

115 patients with non-immune (IgE-negative) urticaria, related to parasitic (lambliasis, oxyuriasis, ascaridiasis) or fungal (candidiasis) associations were investigated-both before and one month after specific and antihistaminic therapy-concerning different percentage levels of blood lymphocyte sets and subsets, by means of flow cytometry. Before therapy, three kinds of immune deficiency patients were obtained, one in lambliasis and oxyuriasis, the second in ascaridiasis, and the third in candidiasis, respectively. Clinical, biological and immunological recovering after therapy exhibited some differences related to the presumed non-allergic etiology, i.e. better in lambliasis and oxyuriasis and worse in ascaridiasis and candidiasis.
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PMID:Pre- and post-therapy blood lymphocyte levels in IgE-negative urticaria, associated with several parasitic or fungal diseases. 925 37

The role of adhesion molecules; the intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) as mediators in development of skin allergy caused by giardiasis and the controlling role of the cytokine interleukin (IL)-6 over these adhesion molecules were studied. The work included 25 symptomatic giardiasis patients with skin allergy manifested by diffuse urticaria, pruritus, wheal and erythema, and had positive serum anti-Giardia immunoglobulin (Ig) E measured as mean optical density (OD) value by enzyme linked immunosorbent assay (ELISA), employed as an evidence of allergic sensitization (G.I). They were compared with 30 symptomatic giardiasis patients (G.II) and 20 apparently healthy control subjects (G.III), both latter groups had negative serum anti-Giardia IgE. The mean OD value of anti-Giardia IgE was significantly increased in G.I (P < 0.01) & insignificantly different in GIII (P > 0.05) compared with G.III. Serum levels of soluble forms of adhesion molecules; sICAM-1 & sVCAM-1, and IL-6 were determined by ELISA. sICAM-1 & sVCAM-1 serum levels were significantly increased (P < 0.001) in G.I compared with G.III and showed insignificant difference (P > 0.05) between Gs. II & III. Serum IL-6 significantly increased in G.I (P < 0.001) & G.II (P < 0.05) compared with G.III, and was significantly higher (P < 0.001) in G.I than G.II. Serum IL-6 correlated positively with serum sICAM-1 (P < 0.01) and sVCAM-1 (P < 0.001) in G.I. The results are discussed.
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PMID:Human giardiasis as an etiology of skin allergy: the role of adhesion molecules and interleukin-6. 1558 2

Three patients with chronic urticaria or pruritus were found to suffer from an asymptomatic intestinal infection caused by the protozoan Giardia lamblia. Treatment with metronidazole per os or tinidazole per os was successful; the pruritic symptoms in one patient improved markedly.Giardia lamblia (Giardia intestinalis) are enteroparasites and produce gastrointestinal symptoms such as acute and chronic diarrhea. Cutaneous manifestations associated with giardiasis occur extremely rarely. Urticaria and itching may be explained as an infection-associated allergy. Hitherto, the following cutaneous signs have been described: urticaria, angioedema, mouth ulcers, pruritus, atopic dermatitis, and anal eczema.We considered that the cutaneous manifestations described here, i. e., urticaria and itching, were secondary to the associated gastrointestinal infection due to Giardia lamblia cysts and trophozoite forms, as they disappeared under specific treatment with metronidazole or tinidazole.
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PMID:[Giardia lamblia--cause of urticaria and pruritus or accidental association?]. 1587 47

We report the case of a 56-year-old female who suffers from chronic urticaria and digestive symptoms, suggesting parasitic infection. Neither repetitive ova and parasite examinations in stools, nor duodenal aspiration examination reveals any parasite. The patient is treated by tinidazole, but the symptoms reappear ten days later. An additive ELISA test on stool remains positive for Giardia Lamblia; the patient receives once more tinidazole and symptoms totally disappear. This case report illustrates that the association between urticaria and digestive symptoms should guide the clinician to the diagnosis of Giardia Lamblia infection, and it shows the importance of a rapid and highly sensitive diagnostic test for giardiasis, like the ELISA test.
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PMID:Chronic urticaria in a middle-aged woman. 2066 87

Infection with Giardia produces a wide range of clinical outcomes. Acutely infected patients may have no overt symptoms or suffer from severe cramps, diarrhea, nausea and even urticaria. Recently, post-infectious irritable bowel syndrome and chronic fatigue syndrome have been identified as long-term sequelae of giardiasis. Frequently, recurrent and chronic Giardia infection is considered a major contributor to stunting in children from low and middle income countries. Perhaps the most unusual outcome of infection with Giardia is the apparent reduced risk of developing moderate-to-severe diarrhea due to other enteric infections which has been noted in several recent studies. The goal of understanding immune responses against Giardia is therefore to identify protective mechanisms which could become targets for vaccine development, but also to identify mechanisms whereby infections lead to these other diverse outcomes. Giardia induces a robust adaptive immune response in both humans and animals. It has been known for many years that there is production of large amounts of parasite-specific IgA following infection and that CD4+ T cell responses contribute to this IgA production and control of the infection. In the past decade, there have been advances in our understanding of the non-antibody effector mechanisms used by the host to fight Giardia infections, in particular the importance of the cytokine interleukin (IL)-17 in orchestrating these responses. There have also been major advances in understanding how the innate response to Giardia infection is initiated and how it contributes to the development of adaptive immunity. Finally, there here have been significant increases in our knowledge of how the resident microbial community influences the immune response and how these responses contribute to the development of some of the symptoms of giardiasis. In this article, we will focus on data generated in the last 10 years and how it has advanced our knowledge about this important parasitic disease.
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PMID:Recent insights into innate and adaptive immune responses to Giardia. 3163 Jul 58


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