Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0017536 (giardiasis)
 1,714 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Because of their distinctive morphology the cysts of Giardia lamblia usually are not mistaken for cysts or eggs of other intestinal parasites. At a hospital laboratory in Kentucky a case of giardiasis was encountered in which the initial fecal examination revealed only degenerated cysts of Giardia which were mistaken for the oocysts of Isospora at the one-sporoblast stage.
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PMID:"Ghost" forms of Giardia lamblia cysts initially misdiagnosed as Isospora. 68 51

In Gabon, 15 children aged 13 to 36 months admitted for malnutrition with chronic diarrhea underwent a small bowel biopsy for detection of parasites in the duodenal contents and histologic evaluation of the intestinal mucosa. In every case, intraepithelial lymphocyte counts (IELC) were under the lower limit of normal for children and adults, regardless of whether or not parasites were found. Partial villous atrophy was a consistent finding. Proportion of lymphocytes among intraepithelial cells was 7.4% in the 6 children with no parasitic infection, 7.9% in the children with giardiasis, and 8.1% in the children with strongyloidiasis. Appropriate treatment of the parasitic infections was quickly followed by resolution of the diarrhea in the nine patients with demonstrable intestinal parasites. These data should be compared with the well documented lymphocyte function anomalies associated with protein-calory malnutrition. The fall in IELC and lack of response to local anigenic stimulations are features of malnutrition.
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PMID:[Decreased intraepithelial lymphocytes in the intestinal mucosa in children with malnutrition and parasitic infections]. 158 May 34

Cases of intestinal giardiasis, spirochetosis, and cryptosporidiosis were examined by scanning electron microscopy (SEM) using hematoxylin and eosin (H&E)-stained tissue sections from which the coverslips were removed and the sections coated with gold. The technique is simple and reliably provides excellent morphologic detail that is preserved in the deparaffinized 4 microsections. We present examples of nine intestinal parasites examined in this manner and compare this technique with standard H&E staining and special stains with regard to relative costs, turnaround time, labor input, and morphologic preservation. Scanning electron microscopy is a useful adjunct in providing confirmatory evidence in the diagnosis of intestinal giardiasis, spirochetosis, and cryptosporidiosis.
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PMID:Correlative light and scanning electron microscopy of intestinal giardiasis, cryptosporidiosis, and spirochetosis. 179 24

An enzyme-linked immunosorbent assay (ELISA) has been evaluated for copro-diagnosis of giardiasis with anti-trophozoite antibody to capture specific Giardia lamblia stool antigen (GLSA), which was then detected by specific antibody conjugated with horseradish peroxidase. GLSA was demonstrated in stool eluates from all the 24 confirmed cases of giardiasis. None of the stool eluates from apparently healthy subjects or from patients carrying intestinal parasites other than G. lamblia had GLSA. Of the 25 microscopy-negative clinically suspected cases of giardiasis, 17 (68%) patients had GLSA in their stool eluates; these patients responded to anti-giardial therapy. The specific antigen was isolated and affinity-purified by the use of specific antibody; it had a Mr of 66 Kda, and its immunoreactivity was lost after treatment with heat or trypsin but unaltered by metaperiodate. ELISA seems to be a sensitive and specific method for copro-diagnosis of giardiasis, especially in highly suspected cases.
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PMID:Enzyme-linked immunosorbent assay for copro-diagnosis of giardiasis and characterisation of a specific Giardia lamblia antigen in stools. 203 May 2

Giardia lamblia, once considered a harmless commensal organism, has become one of the most common pathogenic intestinal parasites. Evidence for various methods of transmission has accumulated and serious physiological and nutritional disturbances as a result of infestation with this parasite have been clinically documented. Giardia lamblia has now been identified as a causative agent of waterborne, foodborne and sexually transmitted infectious diarrhea. Preventive interventions by health education (especially in personal hygiene) are indicated to reduce its spread in the community. The timing of such educational endeavours may be adjusted to the changes in the incidence of giardiasis if such should be predictable insofar as they are rhythmic. Accordingly, monthly totals of positive detected cases of giardiasis reported in Mexico between 1977 and 1985 were first fitted by linear least-squares with a 1-yr cosine curve. Results indicate a predictable circannual variability of Giardia incidence (P less than 0.001), with a crest time situated on the third week of July and monthly means of detected cases above the yearly average incidence between May and September. The validity of this circannual rhythm was further checked by nonlinear least-squares. Results show a presumably 1-yr synchronized estimated period of 8715.1 hr, with a total predictable change (double amplitude of 1788 cases per month) of 43% the average monthly incidence. Moreover, circannual rhythm parameters computed separately for each consecutive year are similar in terms of acrophase (P = 0.771). Awareness of the thus detected circannual predictable variability in the incidence of giardiasis may be important in the prevention, diagnosis and treatment of this infectious disorder. According to the results here found, the timing of prevention interventions by health education should be a readily exploitable factor.
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PMID:Circannual incidence of Giardia lamblia in Mexico. 208 74

An enzyme linked immunosorbent assay (ELISA) system, using monospecific antibodies for the detection of Giardia lamblia specific 66 kDa copro-antigen has been developed and evaluated. The assay detected the antigen in stool eluates of all the 24 microscopically confirmed cases of giardiasis and in 17 (68%) of the 25 microscopy-negative clinically suspected cases of giardiasis. None of stool eluates from 20 subjects infected with other protozoal/helminthic intestinal parasites or from 20 apparently healthy subjects had G. lamblia-specific copro-antigen. The ELISA employing monospecific antibodies is a sensitive and specific tool for the diagnosis of giardiasis and is especially useful for confirming microscopy-negative suspected cases of giardiasis.
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PMID:Evaluation of ELISA for detection of Giardia lamblia-specific copro-antigen employing monospecific antibodies. 129 65

Giardia Lamblia is the flagellated protozoan of intestinal-tract more frequently diagnosed. This disease is well known all over the world, particularly in hot countries and under precarious hygienic-environmental conditions. In Italy the rate of infestation is around 8%. The giardiasis affects people of every age. The disease can be transmitted either by direct contagion or through the ingestion of food contaminated by cysts. Some A.A. believe that in the last years real epidemics in adults occurred, due to the current changing in the habits of life, in particular as regards food and the use of canteens. The italian law demands the competent sanitary authorities to prepare diagnostical procedures for sanitary checks, to be carried out for consignment and renewal of the employment card and for periodical checks on production, manipulation, transport and sale-staff. In a quadrenniale study (1985-1988) the A.A. estimate the incidence of the intestinal parasites and they evaluate the real danger and risks deriving from the contamination of food, by checking 160 canteen-men working in a know metal-mechanical industry in our country, through periodical parasitological stool examination. The parasitological stool exam was carried out bright and after enrichment by Ritchie's method. The Giardia Lamblia, that certainly is the ++intestinal parasite more often isolated in our country, has been observed with varying frequency during the examined period from 1.9% to 5.6%. In 4 years, 38% of these patients, even undergoing specific therapy, has shown relapsing and recurrent infestations both in the following year and later.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Intestinal parasitosis in canteen employees: a quadrennial study]. 248 46

A total of 1,167 stool specimens collected from 0.6-6 years old patients attending King Abdel Aziz University Hospital (KAUH) in Riyadh, were examined for intestinal parasites. Of these 243 (20.8%) were positive. Giardia lamblia (13.5) and Enterobius vermicularis (4.2%), were the commonest parasites found. Other parasites present include Ascaris lumbricoides, Entamoeba histolytica and Hymenolepis nana. Abdominal pain (38.6%) and diarrhoea (27.6%) were the most common causes of referral presented among both males and females examined groups. Out of 211 patients positive for different parasites and showing different causes of referral, 45.5% were accompanied with abdominal pain and 22.3% having pruritus ani, while the percentage of patients having diarrhoea and positive for different parasites (9.5%) are less. It has been concluded that diarrhoea is not a major sign of parasitic infestation in 0.6-6 years old age group. Other causes of referral include, loss of appetite, underweight and failure to thrive which are mainly associated with Giardia lamblia infection.
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PMID:Pattern of intestinal parasitic infection in preschool children in Riyadh, Saudi Arabia. 280 81

A survey was conducted to assess the prevalence of intestinal parasitism in 65 native-born preschool and school-age children living in an unincorporated area of northern Florida. Fifty-seven percent of the children were found to be infected with intestinal parasites. Sixty-eight percent of males surveyed and 47% of females had either single or multiple infections. Prevalence was greatest in the five-10-year-old age group. For the total child population surveyed, parasitic infections in order of most to least prevalent were ascariasis (32%); giardiasis (29%); trichuriasis (14%); and hookworm (2%).
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PMID:The prevalence of intestinal parasites in children living in an unincorporated area in rural northern Florida. 384 79

A study on the prevalence of intestinal parasites in a group of homosexual men, attending a sexually-transmitted diseases clinic in Glasgow, was undertaken. Of 118 men examined over an eight-month period, four, one of whom had symptoms of dysentery, were found to be infected with Entamoeba histolytica. Cysts of Iodamoeba buetschlii were also found in the stool of one of these men. A further two patients had giardiasis, and 11 men had enterobiasis. The importance of an awareness of these conditions is discussed.
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PMID:Intestinal parasites in homosexual men. 625 24


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