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Query: UMLS:C0017536 (giardiasis)
 1,714 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Mb. Whipple is a rare systemic disorder with multiple manifestations. We present a case-story demonstrating the typical course: migrating, non-deforming arthralgies are years later followed by diarrhoea, loss of weight, fatigue and pronounced biochemical disturbances. Intestinal biopsy shows numerous PAS-positive, diastaseresistent macrophages, and antibiotic treatment is initiated. After a somewhat prolonged course, complicated with Giardiasis and endocarditis, the patient recovers. Four months after the cessation of antibiotic treatment, however, the patient shows clinical signs of relapse, and treatment is restarted. The etiological agent has recently been identified as a gram-positive actinomycete called Tropheryma Whippleii. There are some, but not unequivocal, signs of a cellular immunodeficiency, perhaps predestinating certain patients to the disease. The course is usually favourable, when treated with relevant antibiotics. Relapse is not uncommon, and is very problematic when the CNS is involved. Therefore, a combination treatment with good penetration of the blood-brain barrier is recommended--e.g. two weeks treatment with parenterally administered streptomycin and benzylpenicillin followed by sulphamethoxazole-trimethoprim orally for one year.
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PMID:[Whipple disease. A rare systemic disorder with multiple manifestations]. 750 46

The E-rosette-forming capacity of neutrophils and T-lymphocyte counts in the peripheral blood of 21 patients suffering from persistent giardiasis (PG) were found. A control group included 29 healthy persons. The patients with PG showed a significant increase in the count of early and late E-rosette-forming neutrophils along with a substantial decrease in the count of T-lymphocytes, which is indicative of an inflammatory process located mainly in the gallbladder. It is concluded that according to the neutrophil counts, immunodeficiency may not be regarded as a factor predisposing to PG.
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PMID:[Early and late E-rosette-forming neutrophils in persistent lambliasis]. 777 21

A case of 26-year-old male patient is presented. He developed a "sprue-like" syndrome, giardiasis and nodular lymphoid hyperplasia of the gastrointestinal tract. After the immunological study, the common variable immunodeficiency diagnosis was established. Pathogenic and diagnosis aspects were analyzed. Therapeutic response was excellent.
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PMID:[A patient with gastrointestinal manifestations and the common variable immunodeficiency syndrome]. 798 2

In man, as well as in many species of vertebrates there exist several populations of Giardia duodenalis group which, though morphologically indistinguishable, show different level of heterogenicity in several characteristics, a.o. in surface antigens, isoenzyme make-up, RFLP, invasiveness for different hosts or pattern of experimental infection. Also the clinical observations in man distinctly suggested that G. intestinalis comprises several different populations. In the course of giardiasis apparent variability in clinical manifestations can be observed. In many patients the infection is symptomless and resolves spontaneously and in some others--variable intensity of symptoms is observed. Most likely both the parasite's characteristics and the host's feature will determine the clinical character of infection. It is well known that in some cases it is the host that responsible for the symptoms of the infection. Thus, for instance, clinical giardiasis links with immunodeficiency, malnutrition or young age. There are also evidences that some Giardia isolates have enhanced potency to provoke the disease of the host. It is considered that the variable pattern of the infection may be related to three different factors in host-parasite relationship: extra- and intrapopulation variability of Giardia isolates, the microenvironmental factors of the host's intestine, and the variable immune response of the host. The author describes data on the two first factors.
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PMID:[Giardia-host relationship: variation of infection pattern]. 802 3

Trichomonas vaginalis is a common sexually transmitted protozoan parasite. Although often considered simply a nuisance infection, T. vaginalis has been implicated in premature rupture of placental membranes and increases in the risk of acquiring human immunodeficiency virus. Metronidazole, a 5-nitroimidazole, is currently the drug of choice to treat T. vaginalis infection. Because some patients have severe reactions to metronidazole and others are infected with metronidazole-resistant T. vaginalis, we were prompted to investigate alternative therapies. Tinidazole, another 5-nitroimidazole used in other countries to treat T. vaginalis infections, and furazolidone, a nitrofuran presently used to treat giardiasis and infections with some anaerobic enteric bacteria, were investigated for effectiveness against 9 metronidazole-susceptible and 12 metronidazole-resistant T. vaginalis patient isolates. The in vitro aerobic and anaerobic minimum lethal concentrations (MLC) and the time for drug efficacy were determined. Tinidazole killed the metronidazole-susceptible isolates at a low MLC but was effective against only 4 of the 12 metronidazole-resistant isolates. In contrast, furazolidone was effective at a low MLC for all isolates. When tinidazole was effective, it required > 6 h to kill trichomonads. However, furazolidone killed both metronidazole-susceptible and resistant trichomonads within 2 to 3 h of exposure. These data suggest that furazolidone may be a good candidate for treating metronidazole-resistant trichomoniasis and that further investigation of this drug is warranted.
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PMID:In vitro effect of tinidazole and furazolidone on metronidazole-resistant Trichomonas vaginalis. 872 51

Hypokalemic myopathy may occur in several infections. We report a case of severe and transient myopathy secondary to hypokalemia induced by chronic intestinal infection with Giardia lamblia in a patient with common variable hypogammaglobulinemia. Hypokalemic myopathy is documented by serum enzymes, electromyography (reduction in the number of voluntarily activated motor unit action potentials and an increase in polyphasic motor unit action potentials, and pathological changes (hematoxylin-eosin, ATPase staining). The case reported involves hypokalemic myopathy induced by giardiasis in a patient with primary immunodeficiency; the histopathological changes observed in a skin/muscle biopsy from this patient are described for the first time.
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PMID:Giardiasis as a cause of hypokalemic myopathy in congenital immunodeficiency. 885 67

Because the gastrointestinal tract is the largest lymphoid organ in the body, it is not surprising that patients with immunodeficiency would present with pathological conditions in the intestine. Several studies have documented a high prevalence of inflammatory, malignant, and infectious gastrointestinal (GI) disorders in patients with common variable immunodeficiency or immunoglobulin A (IgA) deficiency. Interestingly, it has become increasingly apparent that antibody deficiency alone does not result in GI disease. Rather, defects in cellular immunity appear to predispose to a sprue-like disorder, pernicious anemia, giardiasis, nodular lymphoid hyperplasia, and even inflammatory bowel disease. In patients with unusual inflammatory GI disorders, measurement of serum immunoglobulins should be obtained.
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PMID:Gastrointestinal manifestations of primary immunodeficiency disorders. 900 Apr 99

Protozoan infections represent an area of concern for advanced practice nurses, particularly those working in rural areas or urban environments with refugee populations and those caring for patients with immunodeficiency-related diseases. Some of these infections have major effects on the fetus and neonate yet pose minimal problems to the mother. Protozoan infections are increasing in prevalence because of poor sanitation, overcrowding, increased foreign travel, and high-risk sexual behaviors. There is a need for public education to promote awareness and prevention of such infections. This emerging public health problem has been reported sporadically in the medical and perinatal nursing literature. This paucity of information may be partly due to the difficulty in diagnosing and managing these infections in the perinatal patient. The article discusses the more common infections caused by protozoa, amebae, and sporozoa: trichomoniasis, giardiasis, amebiasis, and toxoplasmosis.
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PMID:Protozoan infection in the perinatal period. 921 49

In this paper, clinical data of 49 adult patients with agammaglobulinaemia (syn. hypogammaglobulinaemia), 15 cases of X-linked agammaglobulinaemia (XLA) and 34 of common variable immunodeficiency (CVID) are reviewed. Although immunoglobulin substitution largely abolished life-threatening respiratory tract infections, considerable infectious and non-infectious morbidity was still encountered in these patients. Almost all patients suffered from chronic or recurrent upper and lower airway infections, mainly caused by Haemophilus influenzae and pneumococci. The lower respiratory tract infections led to cumulative damage to the respiratory tract, especially in XLA patients. Also the incidence of infections outside the respiratory tract (giardiasis, Campylobacter jejuni infections) was more common in XLA patients than in CVID patients. Nodular lymphoid hyperplasia was only found in CVID. A variety of other non-infectious complications were seen especially in CVID. Neoplastic complications occurred in nine patients (two cases of thymoma, two colorectal cancer, one gastric carcinoma, two haematological malignancies, two cases of skin cancer). Six patients died (five XLA patients and one CVID patient, from infectious and non-infectious causes).
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PMID:Hypogammaglobulinaemia: cumulative experience in 49 patients in a tertiary care institution. 1216 71

Psychiatric disorders due to quinacrine for antiparasitic therapy represent an infrequent, but serious, complication. The remarkable course of a 12-year-old boy with common variable immunodeficiency who developed severe psychiatric reactions following quinacrine therapy for his resistant chronic giardiasis is presented. The broad clinical spectrum of quinacrine-associated neuropsychiatric disturbances has been emphasized for the clinicians.
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PMID:Quinacrine-induced psychiatric disturbances in a child with common variable immunodeficiency and chronic giardiasis. 1241 56


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