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Query: UMLS:C0017536 (giardiasis)
 1,714 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Much difficulties are often encountered in finding the underlying cause of recurrent abdominal pain. Clinical features may vary from one patient to the other and occasionally from one episode to the next even in the same child. The recent development of fibre optic endoscopy may well prove to have a useful diagnostic technique, particularly in those children in whom other investigations are inconclusive. The result of endoscopic examinations in children with recurrent abdominal pain comprising of 62 children aged between 3-13 years were as follows: erosion in 7 children, oesophagitis in 4 children, duodenitis in 3 children, spasm of the pylorus in 2 children, and normal findings were found in 30 children. Of the 30 patients with "normal" endoscopic findings, 7 had psychosomatic problems, 4 had allergy, 4 had urinary tract infection, 2 showed giardiasis, one had epilepsy, 1 was treated as pulmonary tuberculosis, where as in 11 patients organic as well as nonorganic abnormalities could not be found. There seem to be of no significant correlation between the endoscopic and upper gastrointestinal series findings. Endoscopy seem to be of a safe and reliable tool in the diagnosis of a number of organic intestinal lesions otherwise not detected by ordinary investigations.
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PMID:Endoscopic examinations in children with recurrent abdominal pain. 248 37

Giardiasis constitutes a very frequent intestinal parasitic infection in our country, with a varied digestive symptomatology. We performed a prospective, transversal study, with the aim to establish the frequency of G. lamblia in digestive symptomatic patients submitted to upper gastrointestinal endoscopy examination trying to relate its isolation with the endoscopic findings. We studied 50 patients; they were submitted to upper endoscopy examination. During the procedure, we aspirated duodenal content and six duodenal biopsies were taken; 8 to 14 hours before endoscopy, they swallowed the Enterotest encapsulated string. The presence of G. lamblia was established by three methods (Enterotest, duodenal content, impront). The day, of the endoscopic examination they resolved a questionnaire of digestive symptoms they had during the last 4 weeks. The endoscopy was informed like normal in 15 patients. (30%). Duodenitis was detected by endoscopy in 9 patients (18%), but neither one of them demonstrated presence of G. lamblia. By the three diagnostic methods, the presence of G. lamblia was demonstrated in 5 patients (19%), without endoscopic duodenitis, being the digestive symptom scores not statistically significant respect to symptomatic patients without G. lamblia. We concluded that the three diagnostic methods used to identify G. lamblia were equally sensitive. No preponderance of digestive symptoms were present in patients with G. lamblia in relation to in our country patients without G. lamblia infection. We recommend to consider duodenal aspiration during endoscopy in order to discard giardiasis.
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PMID:[The prevalence of giardiasis in patients who undergo gastroduodenoscopy]. 800 25

Giardia intestinalis is a common parasite in our country and the rest of the world and is responsible for several clinical disturbances that include dysentery type diarrheas, recurrent abdominal pain, duodenitis, jejunitis, cholecystitis and in some cases toxemias and convulsions. In this paper we review recent concepts of intestinal giardiasis, considering the basic aspects of the biology and physiology of Giardia intestinalis, its morphology and its relationship the parasite pathogenicity. We detail the physiopathological mechanisms responsible for the different clinic manifestations of giardiasis, the specific laboratory and endoscopic methods of diagnosis and the most recent advances in the treatment and prophylaxis of this disease.
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PMID:[Intestinal giardiasis. Mini-review]. 1210 26

Common variable immunodeficiency is characterized by a primary deficiency in antibody production that is clinically manifested by respiratory recurrent infections and gastrointestinal diseases (infectious, inflammatory and neoplastic). Above 50% of the patients have diarrhea and 10% develop idiopathic malabsorption and weight loss. We present the case of a 34-year-old woman submitted to our service for chronic diarrhea, abdominal pain and bloating and history of recurrent respiratory infections since childhood. The laboratory assessment showed severe hypoproteinemia and confirmed low IgG, IgA and IgM levels. Upper gastrointestinal endoscopy and videocapsule endoscopy showed a nodular duodenum with multiple polypoid-like formations all through the small bowel. Histology confirmed chronic duodenitis and Giardia lamblia infection. With the diagnosis of common variable immunodeficiency, monthly intravenous gammaglobulin infusion was initiated and metronidazole was indicated for Giardia lamblia infection achieving excellent clinical and laboratory response.
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PMID:[Common variable immunodeficiency: digestive involvement of a systemic disease]. 2365 Aug 34

Giardiasis is the most common intestinal parasitic infection in the United States. The organism elicits no, or minimal, inflammatory changes in duodenal biopsy samples, so it can be easily overlooked. We performed this study to determine whether Giardia could be isolated from the formalin fixative of biopsy samples, and to evaluate the value of fluid analysis in the assessment for potential infection. We prospectively evaluated duodenal biopsy samples from 92 patients with a clinical suspicion of giardiasis or symptoms compatible with that diagnosis (ie, diarrhea, bloating, or abdominal pain) Biopsy samples were routinely processed and stained with hematoxylin and eosin. Histologic diagnoses included giardiasis (5 cases, 4%), normal findings (64 cases, 70%), peptic injury/active duodenitis (12 cases, 13%), and intraepithelial lymphocytosis with villous blunting (10 cases, 12%). Fifteen cases (13%) showed detached degenerated epithelial cells or mucus droplets in the intervillous space that resembled Giardia. Cytology slides were prepared from formalin in the biopsy container using the standard Cytospin protocol and reviewed by a cytopathologist blinded to the biopsy findings. Cytologic evaluation revealed Giardia spp. in all 5 biopsy-proven cases, and identified an additional case that was not detected by biopsy analysis. Organisms were significantly more numerous (mean: 400 trophozoites; range, 120 to 810) and showed better morphologic features in cytology preparations compared with tissue sections (mean: 129 trophozoites; range, 37 to 253 organisms; P=0.05). Our findings suggest that cytology preparations from formalin fixative can resolve diagnostically challenging cases and even enhance Giardia detection in some cases.
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PMID:Cytology Preparations of Formalin Fixative Aid Detection of Giardia in Duodenal Biopsy Samples. 2976 42