Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0017536 (giardiasis)
 1,714 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 25-year-old male was hospitalized for diarrhea and weight loss. Since childhood he had experienced recurrent episodes of pneumonia and diarrhea. Physical and laboratory findings were compatible with malabsorption. On endoscopy, nodular lymphoid hyperplasia (NLH) of the small intestine was found. Common variable immunodeficiency syndrome (CVID) was suspected and diagnosis was established by demonstrating a significant reduction of plasma gamma-globulin levels. Immediately after starting immunoglobulin treatment diarrhea stopped, and both incidence and severity of pulmonary infections were significantly reduced, while recurrent gastrointestinal infections (notably lambliasis and Campylobacter infections) continued to occur and both bronchiectases and splenomegaly were progressive over years. This case report focuses on CVID as a potential underlying cause of diarrhea. The most important complications of the disease are presented. Therapeutical options are discussed in the light of recently published data.
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PMID:[Diarrhea and weight loss in common variable immunodeficiency]. 1524 8

During 2000-2012, U.S. Air Force Public Health Offices reported 3,429 cases of gastrointestinal infection (GI) diagnosed at Air Force medical treatment facilities. The four most commonly reported specific etiologies of GIs accounted for 86.7% of all GI cases (n=2,972). Salmonellosis accounted for 41.4% (n=1,420) of all cases. The next most commonly reported events were associated with Campylobacter infection, shigellosis, and giardiasis. The majority of GI cases were reported among dependents, most notably among those aged 0-5 years. Campylobacter infections represented a significantly larger proportion of GI reported from locations outside the continental United States (OCONUS) (n=222, 33.7%) compared to continental U.S. (CONUS) locations (n=363, 13.1%). CONUS locations reported higher proportions of salmonellosis, shigellosis, and giardiasis infections compared to OCONUS locations. Annual numbers of reported cases of GI peaked in 2002, declined to much lower numbers during 2004-2007, and then began to climb until the end of the surveillance period.
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PMID:Reported gastrointestinal infections in the U.S. Air Force, 2000-2012. 2497 71