Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0017168 (gastroesophageal reflux disease)
 11,783 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
ADRACALIN 11.4
CAGR1 10.1
ALTE 9.6
calpain 14 9.4
Methylmalonate semialdehyde dehydrogenase 9.4
proton pump 9.0
CAPN14 8.8
Midline-1 8.8
ENaCdelta 8.6
SSR4 8.4
NOX5 protein 8.4
MAS-related G protein-coupled receptor 8.4
BRAVO 8.2
SMA3 8.2
HSAN II 8.2
LIN1 8.1
FHL1B 8.1
AKIRIN2 8.1
LIN2 7.9
basonuclin 2 7.9
KRT23 7.8
Eotaxin-3 7.7
RIMS1 7.7
GOR 7.6
PPP2R5B 7.6
chromodomain helicase DNA binding protein 7 7.6
KEAP1 protein 7.6
NADPH oxidase 5 7.5
EPC2 7.4
ZNF292 7.3
PACS1 7.3
KIAA2022 7.3
SLC5A6 7.3
MUC3A 7.2
ALDH6A1 7.2
PDZRN3 7.2
FRE 7.1
HSAN1 7.0
ADAT3 7.0
ATP2A3 6.9
KRT4 6.9
GPX7 6.9
GNB5 6.9
cathepsin W 6.9
FLG2 6.9
histamine H2 receptor 6.8
CDCA5 6.8
BAI3 6.8
KRT7 6.7
KRT15 6.6
NIPBL 6.5
NRXN2 6.4
IkappaB kinase complex-associated protein 6.4
PERP 6.4
LARS 6.4
PIGN 6.4
RERE 6.4
KRT13 6.4
translocon-associated protein 6.3
OPCML 6.3
TBX18 6.3
SIX4 6.3
ALDOB 6.2
NOX5 6.2
MUC6 6.2
EFNB2 6.2
H+,K+-ATPase 6.1
DLG5 6.1
TEF 6.1
SIDS 6.1
FOXF1 6.1
NEK6 6.1
Bravo 6.1
SYNCRIP 6.0
mucin 4 6.0
CNTN3 6.0
Sepiapterin reductase 6.0
SLC9A6 6.0
AURKC 5.9
PHOSPHO1 5.9
more...
Disease
gastroesophageal reflux disease 11.4
Other esophageal disorders 11.4
Xiphoid syndrome 11.4
Nonspecific esophageal motility disorder 11.4
Cricopharyngeal spasm 10.8
Erosive esophagitis 10.7
Sandifer syndrome 10.7
Pangastritis 10.4
Cricopharyngeal incoordination 10.4
Familial visceral neuropathy 10.4
Reactive gastropathy 10.4
Bile Reflux 10.4
Aneurysm of ascending aorta 10.4
Laryngopharyngeal reflux 10.1
Esophageal atresia/tracheoesophageal fistula 10.1
Drug-induced esophagitis 10.1
Sliding hiatal hernia 10.0
Reflux esophagitis 10.0
hiatal hernia 9.9
chalasia 9.9
esophageal dysmotility 9.9
reflux esophagitis 9.8
Adenocarcinoma of the cardia 9.8
Esophageal erosions 9.8
Diabetic diarrhea 9.8
Gastric motor dysfunction 9.8
Nutcracker esophagus 9.8
Recurrent chest infections 9.8
esophagitis 9.8
Recurrent aspiration pneumonia 9.6
Esophageal adenocarcinoma 9.5
Barrett's esophagus 9.4
Diabetic gastropathy 9.4
Other respiratory disorders 9.4
Gastric hypomotility 9.4
Eosinophilic esophagitis 9.3
laryngitis 9.3
esophageal spasm 9.2
cough variant asthma 9.1
Acute exacerbation of chronic bronchitis 9.1
Intrinsic asthma 9.1
Primary achalasia 9.1
Duodenal web 9.1
Benign oesophageal stricture 9.1
Pill esophagitis 9.1
paraesophageal hernia 9.0
Acute cough 9.0
Chronic gastric volvulus 8.8
diploid/triploid mixoploidy 8.8
achalasia 8.8
Schatzki's ring 8.8
esophageal stricture 8.7
herpes esophagitis 8.7
Chronic esophagitis 8.7
Esophageal dysphagia 8.7
Heller 8.6
Esophageal 8.6
Tooth erosion 8.6
SPG9 8.6
Recurrent upper respiratory tract infections 8.6
Psychogenic cough 8.6
CDG Ix 8.6
geriatric disorder 8.6
Vestibular vertigo 8.6
Cholecystitis and cholelithiasis 8.6
gastrointestinal reflux 8.5
Esophagus 8.4
Esophagus 8.4
hydropneumopericardium 8.4
Mesenteric infarction 8.4
pylorospasm 8.4
esophageal atresia 8.4
Functional dyspepsia 8.3
pharyngolaryngitis 8.3
Intrinsic asthma 8.2
Limited cutaneous systemic sclerosis 8.2
Breathholding 8.2
Recurrent otitis media 8.2
Bronchial compression 8.1
chronic laryngitis 8.1
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Symptom
Intermittent torticollis 11.4
Dysphagia (difficulty swallowing) 11.4
Esophageal chest pain 11.4
Projectile vomiting 11.4
acid regurgitation 10.8
waterbrash 10.4
sternalgia 10.4
heartburn 10.3
Non-cardiac chest pain 10.3
Esophageal pain 9.8
postnasal drip 9.8
ENT symptoms 9.6
belching 9.2
Nasal regurgitation 9.1
Early satiety 8.9
Globus sensation 8.9
Chest wall pain 8.8
chronic cough 8.8
nocturnal cough 8.7
Regurgitation 8.5
retrosternal discomfort 8.3
Bilious vomiting 8.2
Throat symptoms 8.2
Chronic chest pain 8.1
Airway constriction 7.9
muscular incoordination 7.9
Homan's sign 7.8
Night pain 7.8
Poor weight gain 7.8
Persistent vomiting 7.7
regurgitation 7.5
Floppy 7.4
Chest discomfort 7.4
Retrosternal pain 7.4
persistent cough 7.3
Burning pain 7.2
Infantile colic 7.1
Thoracic pain 7.1
Respiratory abnormalities 7.0
bloating 6.9
Swallowing problems 6.8
epigastric distress 6.8
vasovagal attacks 6.8
hoarseness 6.7
voice change 6.7
Motor dysfunction 6.6
Multiple symptoms 6.6
Postoperative vomiting 6.5
painful swallowing 6.4
Respiratory symptoms 6.3
retching 6.3
Orthostasis 6.3
stridor 6.2
Gastrointestinal symptoms 6.2
Food intolerance 6.2
chest pain 6.2
epigastric pain 6.0
wheezing 5.9
Darier's sign 5.8
cough 5.8
cardialgia 5.7
exertional chest pain 5.7
atypical chest pain 5.7
chronic constipation 5.6
drooling 5.6
pressure in the ear 5.6
abnormal reflex 5.6
non-productive cough 5.6
Chronic abdominal pain 5.6
throat irritation 5.5
Visceral pain 5.5
constipation 5.5
Functional constipation 5.5
Gasping 5.5
vomiting 5.5
aphonia 5.5
incoordination 5.1
stomach pain 5.0
prominent nose 5.0
Overlying 5.0
more...
Drug
Pariet 10.3
Protonix 10.2
Pantoprazole sodium 10.1
Nexium 9.8
Itopride hydrochloride 9.4
Roxatidine acetate hydrochloride 9.4
Tenatoprazole 9.4
Propulsid 9.4
Cisapride 8.6
Omeprazole 8.3
Primperan 8.0
Dramamine 7.7
Zinga 7.5
Sevelamer carbonate 7.5
Dimethicone 7.5
Histalog 7.3
Tilade 7.3
Darvon 7.2
Riopan 7.0
Thioproline 7.0
Clebopride 7.0
Carafate 6.9
Sincalide 6.9
Gastrozepin 6.8
Alendronate sodium 6.8
Gastro 6.7
Buscopan 6.7
Histalog 6.5
Sucralfate 6.5
Polaprezinc 6.4
Metoclopramide hydrochloride 6.4
Tegaserod 6.3
Gastrozepin 6.2
Plaquenil 6.0
Plaquenil 6.0
Tegaserod 6.0
Maalox 6.0
Rioprostil 5.9
CEG 5.9
Norcuron 5.9
Atrovent 5.8
CEG 5.7
Singulair 5.6
DEL 5.6
Cordarone 5.5
Dextropropoxyphene 5.4
Ranitidine 5.3
Ranitidine hydrochloride 5.3
Botox 5.3
Cordarone 5.2
Fosamax 5.2
Enprofylline 5.2
Nicorette 5.2
Catapres 5.2
Kayexalate 5.1
Sodium alginate 5.1
Mepolizumab 5.0
Muse 4.9
GNA 4.9
Domperidone 4.8
Ipratropium bromide 4.7
EDR 4.6
Sevelamer 4.6
Cimetidine 4.6
Atropine sulfate 4.6
Cimetidine 4.6
Pirfenidone 4.5
Pepstatin 4.4
Lugol's solution 4.4
Misoprostol 4.3
Xanthan gum 4.2
Rebamipide 4.2
Mirtazapine 4.1
Asthma 3.9
OTC 3.9
Nedocromil sodium 3.8
Lugol 3.8
ENT 3.7
Omalizumab 3.7
Poloxamer 188 3.6
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Enzyme
GDP-L-fucose synthase 8.1
PHOSPHO1 5.9
GDP-mannose 4,6-dehydratase 5.8
pepsin 5.3
methylcrotonyl-CoA carboxylase 4.9
gastricsin 4.8
SOR 4.4
PFI 3.8
PMT 3.8
pantothenate kinase 3.5
urease 3.4
urease 3.3
myrosinase 3.2
CDH 3.2
H,K-ATPase 3.2
LIS 3.1
phosphoglycerate dehydrogenase 3.1
Fpg protein 3.0
SOR 2.9
PAT 2.7
ornithine transcarbamylase 2.7
CYP3A4 2.5
BAL 2.5
TRS 2.4
lactase 2.3
tryptase 2.3
arylsulfatase A 2.1
p-nitrophenylphosphatase 2.1
NAT 2.0
GCA 2.0
glucocerebrosidase 1.9
MCS 1.8
GABA transaminase 1.7
galactose oxidase 1.7
PST 1.7
12-lipoxygenase 1.7
KAT 1.6
AOR 1.6
SPT 1.6
ACE 1.6
GAS 1.5
DCF 1.5
flavin-containing monooxygenase 1.3
3-hydroxy-3-methylglutaryl-CoA reductase 1.3
ATPase 1.2
arylsulfatase 1.1
lysyl oxidase 1.1
transketolase 1.1
NADPH-diaphorase 1.1
myosin light chain kinase 1.0
beta-glucosidase 0.9
CAD 0.9
histidine decarboxylase 0.9
CAD 0.9
CAD 0.8
trypsin 0.8
MIP 0.7
beta-glucosidase 0.7
phosphodiesterase 0.7
prolyl hydroxylase 0.6
NOS 0.6
phytase 0.4
phytase 0.4
NQO1 0.4
soluble epoxide hydrolase 0.3
N-acetyltransferase 0.2
IKK 0.1
NADPH oxidase 0.1
alpha-amylase 0.0
MDP 0.0
DNA ligase -0.0
DNA ligase -0.0
diaphorase -0.0
NADPH oxidase -0.1
carboxylesterase -0.1
protein phosphatase 2A -0.2
AST -0.2
lipase -0.2
NO synthase -0.2
sulfatase -0.2
more...
Compound
Rabeprazole 9.8
Difenoxin 9.4
Diphemanil 9.1
Pantoprazole 8.9
Rabeprazole sodium 8.9
Cisapride 8.6
Omeprazole 8.1
Lansoprazole 7.9
Nizatidine 7.7
Myosmine 7.5
PPI 7.4
Bethanechol 7.3
Acotiamide 7.2
Metoclopramide hydrochloride 7.1
Metoclopramide 6.7
Glycochenodeoxycholic acid 6.6
Sudan Red 6.6
Sucralfate 6.5
6-pyruvoyltetrahydropterin 6.4
Germin 6.1
barium 6.1
Ranitidine 6.0
Domperidone 5.9
Delavirdine 5.9
Lubiprostone 5.9
Prochlorperazine 5.8
8-HETE 5.8
Baclofen 5.8
Dimenhydrinate 5.6
2-methoxybenzamide 5.5
Lithocholic acid 5.3
DCI 5.2
TIF 5.2
Prone 4.8
Sodium deoxycholate 4.8
Atropine sulfate 4.7
APO 4.7
Paricalcitol 4.6
Chenodeoxycholic acid 4.6
Edrophonium 4.6
Glycopyrrolate 4.6
3-methylcrotonyl-CoA 4.5
Mirtazapine 4.4
Pentagastrin 4.3
SAN 4.3
DTB 4.3
DTB 4.3
Deoxycholic acid 4.3
Indigo Carmine 4.3
DTB 4.2
Pirenzepine 4.2
TFF 4.2
BayK8644 4.1
IBP 4.1
IBP 4.1
Azithromycin 3.9
IDA 3.8
PMT 3.8
Sulbactam 3.7
Aristolochic acid 3.7
Nitrazepam 3.7
Sibutramine 3.7
F23 3.6
Alginate 3.6
Relaxant 3.6
Triamcinolone acetonide 3.6
Lipoxin A4 3.5
G17 3.5
Hydroxychloroquine 3.5
Triamcinolone 3.5
PDP 3.5
Pepstatin 3.5
Erythromycin 3.5
OMP 3.4
Azan 3.4
T 1 3.4
INN 3.4
isopentenyl diphosphate 3.4
ECP 3.4
Aminophylline 3.3
more...