Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0017168 (gastroesophageal reflux disease)
11,783 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
proton pump 1497
Sep 774
gastrin 111
She 111
gut 105
reserved 95
Pol 67
Mol 67
FRE 59
collagen 52
insulin 46
ATPase 45
cytokine 44
p53 43
ENT 42
ENG 41
IgE 40
CYP2C19 40
GABA 37
IL-8 32
IL-6 28
MRI 28
cytochrome P450 27
cholecystokinin 26
substance P 25
calcium channel 25
COPD 24
ghrelin 23
mucin 23
tumor necrosis factor 22
leptin 22
B12 20
histamine H2 receptor 20
cyclooxygenase-2 19
TNF 18
hemoglobin 18
GABA(B) receptor 18
SPA 18
FEV 18
COX-2 18
somatostatin 17
ACE 16
IL-5 16
CO2 15
PGA 15
motilin 15
lymphoid 15
Bravo 14
MUC2 14
SIDS 14
MUC6 14
CYP3A4 13
ATP 13
inducible nitric oxide synthase 13
glucagon 13
mast cell 13
adenosine triphosphatase 13
casein 13
Gen 13
CDX2 13
TEF 13
ICD 12
Mal 12
epidermal growth factor 12
pepsinogen 12
MUC5AC 12
CPAP 12
TRPV1 12
nitric oxide synthase 12
phosphodiesterase 11
albumin 11
JAMA 11
metabotropic glutamate receptor 10
p38 10
nodal 10
Ki-67 10
secretin 10
CD4 10
MAPK 10
CCK 10
more...
Disease
gastroesophageal reflux disease 11783
esophagitis 1879
Barrett's esophagus 1385
dysphagia 1075
Esophageal 983
adenocarcinoma 887
asthma 857
cancer 707
hiatal hernia 705
reflux esophagitis 515
obesity 479
achalasia 456
dyspepsia 437
dysplasia 398
Esophagus 380
Esophagus 380
peptic ulcer 365
carcinoma 263
gastritis 256
tumor 243
hernia 216
gastric cancer 197
Helicobacter pylori infection 193
diabetes 183
esophageal cancer 177
pneumonia 176
esophageal atresia 175
esophageal cancer 167
irritable bowel syndrome 166
Esophageal adenocarcinoma 165
failure to thrive 163
duodenal ulcer 155
esophageal dysmotility 150
hypertension 149
laryngitis 142
esophageal stricture 141
Heller 132
Eosinophilic esophagitis 129
depression 127
obstructive sleep apnea 118
carcinogenesis 117
chronic obstructive pulmonary disease 114
aspiration pneumonia 113
lung disease 103
Best 102
cystic fibrosis 102
squamous cell carcinoma 99
gastroparesis 96
atrophic gastritis 95
sleep apnea 93
PSS 93
respiratory disease 91
idiopathic pulmonary fibrosis 86
eosinophilia 86
malnutrition 86
scleroderma 86
esophageal spasm 85
bronchitis 82
bronchitis 81
gastric ulcer 81
anemia 79
sinusitis 76
chronic disease 73
gallstones 64
inflammatory bowel disease 64
coronary artery disease 63
sudden infant death syndrome 62
cerebral palsy 62
morbid obesity 61
gastrointestinal disease 60
epilepsy 60
recurrent pneumonia 59
Zollinger-Ellison syndrome 58
bronchiectasis 55
paraesophageal hernia 54
bronchiolitis 53
premalignant condition 53
osteoporosis 52
tracheomalacia 52
developmental delay 52
more...
Symptom
heartburn 1019
regurgitation 564
vomiting 528
cough 480
chest pain 462
pain 431
chronic cough 327
abdominal pain 189
constipation 174
anesthesia 163
diarrhea 154
acidity 153
nausea 134
discomfort 115
hoarseness 115
discomfort 111
acid regurgitation 109
dyspnea 105
wheezing 105
seizures 94
belching 93
epigastric pain 84
postnasal drip 83
bloating 76
stridor 65
respiratory distress 60
angina 60
overweight 50
hypotonia 46
ENT 42
erythema 39
headache 37
anorexia 37
persistent cough 36
spasm 36
fatigue 33
sore throat 31
nausea and vomiting 30
weakness 29
cyanosis 29
Wind 27
sleepiness 25
colic 25
collapse 25
Regurgitation 24
dystonia 23
chronic constipation 23
incoordination 22
insomnia 21
nocturnal cough 17
syncope 17
snoring 16
retching 16
Gastrointestinal symptoms 16
spasticity 15
torticollis 15
back pain 15
Respiratory symptoms 14
analgesia 14
dizziness 13
ENT symptoms 13
drooling 12
atypical chest pain 12
Ill 11
hemoptysis 11
hypertonia 11
hypercapnia 10
paresis 10
shortness of breath 10
agitation 9
distraction 9
cachexia 9
tremor 8
Non-cardiac chest pain 8
hepatosplenomegaly 7
exertional dyspnea 7
hunger 7
abdominal discomfort 7
hypothermia 7
chest tightness 7
more...
Drug
Asthma 143
Omeprazole 118
Cardiovasc 88
Cisapride 48
ENT 42
Gastro 36
Ranitidine 24
caffeine 18
Cimetidine 15
Cimetidine 14
Monit 13
Histamine 10
lactose 10
Nexium 10
ascorbate 10
Sucralfate 9
Leaf 8
Pariet 8
citric acid 7
Domperidone 7
ROC 7
Botox 6
Primperan 6
Allergen 6
CSF 6
Atropine 6
Theophylline 6
Dial 6
DEL 6
nitroglycerin 6
ROS 5
Azithromycin 5
ampicillin 5
Pantoprazole sodium 5
Misoprostol 4
OTC 4
OTC 4
ADM 4
Bifidobacterium 3
Gel 3
Buscopan 3
Fraction 3
IL-1ra 3
Dermatol 3
Diurnal 3
Protonix 3
Maalox 3
Propulsid 3
Dakar 3
TAK 3
GNA 3
EDR 3
Sodium alginate 3
Ethanol 3
Scopolamine 3
Glucagon 2
Citric acid 2
Tegaserod 2
Diphenhydramine 2
ACT 2
vitamin E 2
Itopride hydrochloride 2
Vitamin B12 2
Methylene blue 2
IFN-gamma 2
Lugol 2
Tegaserod 2
Triclosan 2
lysine 2
Glutathione 2
Clonidine 2
Atrovent 2
PTH 2
Omalizumab 2
OMP 2
Propofol 2
IL-2 2
Vicryl 2
Hypaque 2
Gabapentin 2
more...
Enzyme
pepsin 129
ATPase 57
urease 28
urease 28
trypsin 27
ACE 20
mitogen-activated protein kinase 17
ERK 17
CYP3A4 13
phosphodiesterase 11
peroxidase 10
protein kinase C 7
catalase 7
superoxide dismutase 7
lipase 6
aspartate aminotransferase 6
alanine aminotransferase 6
tryptase 5
glutathione peroxidase 5
NO synthase 5
APC 5
ornithine transcarbamylase 4
NADPH oxidase 4
protein kinase 4
NADPH oxidase 4
NOS 4
acetylcholinesterase 4
BAL 4
MEK 4
lactase 4
CAD 3
CAD 3
CAD 3
ACS 3
luciferase 3
glutathione S-transferase 3
NADPH-diaphorase 3
focal adhesion kinase 3
NQO1 3
MIP 3
elastase 2
beta-glucosidase 2
SOR 2
papain 2
DCF 2
RNA polymerase 2
PMT 2
PAT 2
reverse transcriptase 2
alpha-amylase 2
myrosinase 2
AOR 2
IKK 2
phosphatidylinositol 3-kinase 2
CD10 2
cholinesterase 2
monoamine oxidase 2
myosin light chain kinase 2
glucocerebrosidase 2
CDH 2
SOR 2
renin 2
carbonic anhydrase 2
endonuclease 2
plasmin 2
AST 2
beta-glucosidase 2
PST 1
transglutaminase 1
TRS 1
proteasome 1
ATP synthase 1
P-glycoprotein 1
transketolase 1
LIS 1
calcineurin 1
aldehyde dehydrogenase 1
prolyl hydroxylase 1
protein phosphatase 2A 1
gastricsin 1
more...
Compound
Clin 1205
Dec 802
barium 401
water 170
PPI 135
Omeprazole 122
oxygen 112
DNA 92
nitric oxide 85
calcium 78
sodium 69
potassium 63
glucose 59
His 59
HCl 57
hydrogen 55
Cisapride 46
Rabeprazole 39
CO2 39
GABA 37
GABA 37
iron 33
urea 31
ethanol 30
salt 30
Metoclopramide 28
Lansoprazole 26
acetate 26
Baclofen 25
Pantoprazole 25
Optimal 23
Ranitidine 22
sulfate 21
phosphate 20
Cardiol 19
caffeine 18
glutamate 18
TNF 18
ASA 18
bromide 15
nitrogen 15
carbonate 14
ammonia 14
ATP 13
APO 13
A 3 12
arginine 12
creatinine 12
nitrate 11
gamma-aminobutyric acid 11
Bethanechol 10
galactose 10
PGE2 10
Histamine 10
phosphorus 9
Sucralfate 9
tryptophan 8
6-12 8
Estrogen 8
Theophylline 8
cysteine 8
aluminum 8
Pac 8
Domperidone 8
iodine 8
Melatonin 7
A 1 7
Alginate 7
Nizatidine 7
THE 7
NH2 7
tryptophan 7
PEG 7
tryptophan 6
Erythromycin 6
zinc 6
vitamin D 6
Dial 6
5-HT 6
acetic acid 6
more...