Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0017168 (
gastroesophageal reflux disease
)
11,783
document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
proton pump
1497
Sep
774
gastrin
111
She
111
gut
105
reserved
95
Pol
67
Mol
67
FRE
59
collagen
52
insulin
46
ATPase
45
cytokine
44
p53
43
ENT
42
ENG
41
IgE
40
CYP2C19
40
GABA
37
IL-8
32
IL-6
28
MRI
28
cytochrome P450
27
cholecystokinin
26
substance P
25
calcium channel
25
COPD
24
ghrelin
23
mucin
23
tumor necrosis factor
22
leptin
22
B12
20
histamine H2 receptor
20
cyclooxygenase-2
19
TNF
18
hemoglobin
18
GABA(B) receptor
18
SPA
18
FEV
18
COX-2
18
somatostatin
17
ACE
16
IL-5
16
CO2
15
PGA
15
motilin
15
lymphoid
15
Bravo
14
MUC2
14
SIDS
14
MUC6
14
CYP3A4
13
ATP
13
inducible nitric oxide synthase
13
glucagon
13
mast cell
13
adenosine triphosphatase
13
casein
13
Gen
13
CDX2
13
TEF
13
ICD
12
Mal
12
epidermal growth factor
12
pepsinogen
12
MUC5AC
12
CPAP
12
TRPV1
12
nitric oxide synthase
12
phosphodiesterase
11
albumin
11
JAMA
11
metabotropic glutamate receptor
10
p38
10
nodal
10
Ki-67
10
secretin
10
CD4
10
MAPK
10
CCK
10
more...
Disease
gastroesophageal reflux disease
11783
esophagitis
1879
Barrett's esophagus
1385
dysphagia
1075
Esophageal
983
adenocarcinoma
887
asthma
857
cancer
707
hiatal hernia
705
reflux esophagitis
515
obesity
479
achalasia
456
dyspepsia
437
dysplasia
398
Esophagus
380
Esophagus
380
peptic ulcer
365
carcinoma
263
gastritis
256
tumor
243
hernia
216
gastric cancer
197
Helicobacter pylori infection
193
diabetes
183
esophageal cancer
177
pneumonia
176
esophageal atresia
175
esophageal cancer
167
irritable bowel syndrome
166
Esophageal adenocarcinoma
165
failure to thrive
163
duodenal ulcer
155
esophageal dysmotility
150
hypertension
149
laryngitis
142
esophageal stricture
141
Heller
132
Eosinophilic esophagitis
129
depression
127
obstructive sleep apnea
118
carcinogenesis
117
chronic obstructive pulmonary disease
114
aspiration pneumonia
113
lung disease
103
Best
102
cystic fibrosis
102
squamous cell carcinoma
99
gastroparesis
96
atrophic gastritis
95
sleep apnea
93
PSS
93
respiratory disease
91
idiopathic pulmonary fibrosis
86
eosinophilia
86
malnutrition
86
scleroderma
86
esophageal spasm
85
bronchitis
82
bronchitis
81
gastric ulcer
81
anemia
79
sinusitis
76
chronic disease
73
gallstones
64
inflammatory bowel disease
64
coronary artery disease
63
sudden infant death syndrome
62
cerebral palsy
62
morbid obesity
61
gastrointestinal disease
60
epilepsy
60
recurrent pneumonia
59
Zollinger-Ellison syndrome
58
bronchiectasis
55
paraesophageal hernia
54
bronchiolitis
53
premalignant condition
53
osteoporosis
52
tracheomalacia
52
developmental delay
52
more...
Symptom
heartburn
1019
regurgitation
564
vomiting
528
cough
480
chest pain
462
pain
431
chronic cough
327
abdominal pain
189
constipation
174
anesthesia
163
diarrhea
154
acidity
153
nausea
134
discomfort
115
hoarseness
115
discomfort
111
acid regurgitation
109
dyspnea
105
wheezing
105
seizures
94
belching
93
epigastric pain
84
postnasal drip
83
bloating
76
stridor
65
respiratory distress
60
angina
60
overweight
50
hypotonia
46
ENT
42
erythema
39
headache
37
anorexia
37
persistent cough
36
spasm
36
fatigue
33
sore throat
31
nausea and vomiting
30
weakness
29
cyanosis
29
Wind
27
sleepiness
25
colic
25
collapse
25
Regurgitation
24
dystonia
23
chronic constipation
23
incoordination
22
insomnia
21
nocturnal cough
17
syncope
17
snoring
16
retching
16
Gastrointestinal symptoms
16
spasticity
15
torticollis
15
back pain
15
Respiratory symptoms
14
analgesia
14
dizziness
13
ENT symptoms
13
drooling
12
atypical chest pain
12
Ill
11
hemoptysis
11
hypertonia
11
hypercapnia
10
paresis
10
shortness of breath
10
agitation
9
distraction
9
cachexia
9
tremor
8
Non-cardiac chest pain
8
hepatosplenomegaly
7
exertional dyspnea
7
hunger
7
abdominal discomfort
7
hypothermia
7
chest tightness
7
more...
Drug
Asthma
143
Omeprazole
118
Cardiovasc
88
Cisapride
48
ENT
42
Gastro
36
Ranitidine
24
caffeine
18
Cimetidine
15
Cimetidine
14
Monit
13
Histamine
10
lactose
10
Nexium
10
ascorbate
10
Sucralfate
9
Leaf
8
Pariet
8
citric acid
7
Domperidone
7
ROC
7
Botox
6
Primperan
6
Allergen
6
CSF
6
Atropine
6
Theophylline
6
Dial
6
DEL
6
nitroglycerin
6
ROS
5
Azithromycin
5
ampicillin
5
Pantoprazole sodium
5
Misoprostol
4
OTC
4
OTC
4
ADM
4
Bifidobacterium
3
Gel
3
Buscopan
3
Fraction
3
IL-1ra
3
Dermatol
3
Diurnal
3
Protonix
3
Maalox
3
Propulsid
3
Dakar
3
TAK
3
GNA
3
EDR
3
Sodium alginate
3
Ethanol
3
Scopolamine
3
Glucagon
2
Citric acid
2
Tegaserod
2
Diphenhydramine
2
ACT
2
vitamin E
2
Itopride hydrochloride
2
Vitamin B12
2
Methylene blue
2
IFN-gamma
2
Lugol
2
Tegaserod
2
Triclosan
2
lysine
2
Glutathione
2
Clonidine
2
Atrovent
2
PTH
2
Omalizumab
2
OMP
2
Propofol
2
IL-2
2
Vicryl
2
Hypaque
2
Gabapentin
2
more...
Enzyme
pepsin
129
ATPase
57
urease
28
urease
28
trypsin
27
ACE
20
mitogen-activated protein kinase
17
ERK
17
CYP3A4
13
phosphodiesterase
11
peroxidase
10
protein kinase C
7
catalase
7
superoxide dismutase
7
lipase
6
aspartate aminotransferase
6
alanine aminotransferase
6
tryptase
5
glutathione peroxidase
5
NO synthase
5
APC
5
ornithine transcarbamylase
4
NADPH oxidase
4
protein kinase
4
NADPH oxidase
4
NOS
4
acetylcholinesterase
4
BAL
4
MEK
4
lactase
4
CAD
3
CAD
3
CAD
3
ACS
3
luciferase
3
glutathione S-transferase
3
NADPH-diaphorase
3
focal adhesion kinase
3
NQO1
3
MIP
3
elastase
2
beta-glucosidase
2
SOR
2
papain
2
DCF
2
RNA polymerase
2
PMT
2
PAT
2
reverse transcriptase
2
alpha-amylase
2
myrosinase
2
AOR
2
IKK
2
phosphatidylinositol 3-kinase
2
CD10
2
cholinesterase
2
monoamine oxidase
2
myosin light chain kinase
2
glucocerebrosidase
2
CDH
2
SOR
2
renin
2
carbonic anhydrase
2
endonuclease
2
plasmin
2
AST
2
beta-glucosidase
2
PST
1
transglutaminase
1
TRS
1
proteasome
1
ATP synthase
1
P-glycoprotein
1
transketolase
1
LIS
1
calcineurin
1
aldehyde dehydrogenase
1
prolyl hydroxylase
1
protein phosphatase 2A
1
gastricsin
1
more...
Compound
Clin
1205
Dec
802
barium
401
water
170
PPI
135
Omeprazole
122
oxygen
112
DNA
92
nitric oxide
85
calcium
78
sodium
69
potassium
63
glucose
59
His
59
HCl
57
hydrogen
55
Cisapride
46
Rabeprazole
39
CO2
39
GABA
37
GABA
37
iron
33
urea
31
ethanol
30
salt
30
Metoclopramide
28
Lansoprazole
26
acetate
26
Baclofen
25
Pantoprazole
25
Optimal
23
Ranitidine
22
sulfate
21
phosphate
20
Cardiol
19
caffeine
18
glutamate
18
TNF
18
ASA
18
bromide
15
nitrogen
15
carbonate
14
ammonia
14
ATP
13
APO
13
A 3
12
arginine
12
creatinine
12
nitrate
11
gamma-aminobutyric acid
11
Bethanechol
10
galactose
10
PGE2
10
Histamine
10
phosphorus
9
Sucralfate
9
tryptophan
8
6-12
8
Estrogen
8
Theophylline
8
cysteine
8
aluminum
8
Pac
8
Domperidone
8
iodine
8
Melatonin
7
A 1
7
Alginate
7
Nizatidine
7
THE
7
NH2
7
tryptophan
7
PEG
7
tryptophan
6
Erythromycin
6
zinc
6
vitamin D
6
Dial
6
5-HT
6
acetic acid
6
more...