Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0017168 (gastroesophageal reflux disease)
 11,783 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
proton pump 1497
Sep 774
gastrin 111
She 111
gut 105
reserved 95
Mol 67
Pol 67
FRE 59
collagen 52
insulin 46
ATPase 45
cytokine 44
p53 43
ENT 42
ENG 41
CYP2C19 40
IgE 40
GABA 37
IL-8 32
MRI 28
IL-6 28
cytochrome P450 27
cholecystokinin 26
calcium channel 25
substance P 25
COPD 24
ghrelin 23
mucin 23
leptin 22
tumor necrosis factor 22
histamine H2 receptor 20
B12 20
cyclooxygenase-2 19
COX-2 18
hemoglobin 18
SPA 18
GABA(B) receptor 18
FEV 18
TNF 18
somatostatin 17
IL-5 16
ACE 16
lymphoid 15
motilin 15
PGA 15
CO2 15
MUC2 14
SIDS 14
Bravo 14
MUC6 14
inducible nitric oxide synthase 13
TEF 13
casein 13
glucagon 13
ATP 13
mast cell 13
adenosine triphosphatase 13
Gen 13
CYP3A4 13
CDX2 13
pepsinogen 12
TRPV1 12
MUC5AC 12
nitric oxide synthase 12
ICD 12
epidermal growth factor 12
Mal 12
CPAP 12
JAMA 11
phosphodiesterase 11
albumin 11
Ki-67 10
interleukin-6 10
p38 10
secretin 10
chemokine 10
CD4 10
nodal 10
MAPK 10
polypeptide 10
CCK 10
metabotropic glutamate receptor 10
cage 10
IL-4 9
IL-13 9
GOR 9
Hop 9
ASA 9
transient receptor potential vanilloid 1 9
Pseudomonas 9
IMAC 9
X-linked 9
CK7 9
p63 9
C-reactive protein 9
adiponectin 9
ALTE 8
mGluR5 8
Rec 8
cyclin D1 8
IgA 8
CK20 8
San 8
CRP 8
cytokeratin 8
IL-10 8
ANOVA 8
EAC 7
strabismus 7
pancreatic polypeptide 7
p16 7
superoxide dismutase 7
BID 7
p65 7
myeloperoxidase 7
neurotensin 7
E-cadherin 7
SMA 7
CAB 7
vasoactive intestinal peptide 7
cyclooxygenase 2 7
HET 6
TNF-alpha 6
NMR 6
lipopolysaccharide 6
muscarinic receptor 6
beta-endorphin 6
membrane-bound 6
growth hormone 6
short form 6
CD8 6
NIPBL 6
catalase 6
STAT3 6
occludin 6
kit 6
REM 6
bradykinin 6
homeobox 6
chronic renal failure 6
Was 5
Leptin 5
Nei 5
Cytokine 5
estrogen receptor 5
MIB 5
ROS 5
5-hydroxytryptamine 5
beta-catenin 5
Men 5
villin 5
IPP 5
insulin-like growth factor 5
vasoactive intestinal peptide (VIP) 5
MUC1 5
chromogranin A 5
enigma 5
BAR 5
thymic stromal lymphopoietin 5
more...
Disease
gastroesophageal reflux disease 11783
esophagitis 1879
Barrett's esophagus 1385
dysphagia 1075
Esophageal 983
adenocarcinoma 887
asthma 857
cancer 707
hiatal hernia 705
reflux esophagitis 515
obesity 479
achalasia 456
dyspepsia 437
dysplasia 398
Esophagus 380
Esophagus 380
peptic ulcer 365
carcinoma 263
gastritis 256
tumor 243
hernia 216
gastric cancer 197
Helicobacter pylori infection 193
diabetes 183
esophageal cancer 177
pneumonia 176
esophageal atresia 175
esophageal cancer 167
irritable bowel syndrome 166
Esophageal adenocarcinoma 165
failure to thrive 163
duodenal ulcer 155
esophageal dysmotility 150
hypertension 149
laryngitis 142
esophageal stricture 141
Heller 132
Eosinophilic esophagitis 129
depression 127
obstructive sleep apnea 118
carcinogenesis 117
chronic obstructive pulmonary disease 114
aspiration pneumonia 113
lung disease 103
cystic fibrosis 102
Best 102
squamous cell carcinoma 99
gastroparesis 96
atrophic gastritis 95
sleep apnea 93
PSS 93
respiratory disease 91
eosinophilia 86
scleroderma 86
malnutrition 86
idiopathic pulmonary fibrosis 86
esophageal spasm 85
bronchitis 82
gastric ulcer 81
bronchitis 81
anemia 79
sinusitis 76
chronic disease 73
gallstones 64
inflammatory bowel disease 64
coronary artery disease 63
sudden infant death syndrome 62
cerebral palsy 62
morbid obesity 61
epilepsy 60
gastrointestinal disease 60
recurrent pneumonia 59
Zollinger-Ellison syndrome 58
bronchiectasis 55
paraesophageal hernia 54
premalignant condition 53
bronchiolitis 53
tracheomalacia 52
osteoporosis 52
developmental delay 52
allergic rhinitis 51
bowel obstruction 51
pulmonary hypertension 50
rhinitis 50
celiac disease 46
Reflux esophagitis 46
sepsis 46
food allergy 46
bronchospasm 45
West 45
cirrhosis 45
rumination 45
sepsis 44
esophageal varices 44
type 2 diabetes 43
scoliosis 42
Crohn's disease 41
dyskinesia 41
interstitial lung disease 41
volvulus 40
prematurity 40
sleep disorders 39
confusion 38
tumor progression 38
sleep disturbances 38
mucosa-associated lymphoid tissue 38
otitis media 38
Down syndrome 37
infectious diseases 37
chronic bronchitis 36
mental retardation 35
heart disease 35
mental retardation 35
carditis 34
bronchopulmonary dysplasia 34
ischemia 34
malabsorption 33
respiratory failure 33
laryngospasm 33
metastases 33
dyslipidemia 33
cardiovascular disease 33
pulmonary fibrosis 32
Adenocarcinoma 32
ileus 32
immunodeficiency 32
chronic sinusitis 31
emphysema 31
lung cancer 30
dysphonia 30
metabolic syndrome 30
liver disease 30
abdominal obesity 29
Laryngopharyngeal reflux 29
carcinoma of the esophagus 29
Sandifer syndrome 28
SEM 28
Functional dyspepsia 28
connective tissue disease 28
cold 28
colorectal cancer 28
stroke 27
Infection 27
dumping syndrome 27
middle ear 26
pancreatitis 26
dehydration 26
myocardial ischemia 26
duodenitis 26
congestive heart failure 26
pneumothorax 26
COPD 24
tooth wear 24
heart failure 24
enteropathy 23
Zenker's diverticulum 23
lymphoma 23
aggression 22
virus infection 22
varices 22
more...
Symptom
heartburn 1019
regurgitation 564
vomiting 528
cough 480
chest pain 462
pain 431
chronic cough 327
abdominal pain 189
constipation 174
anesthesia 163
diarrhea 154
acidity 153
nausea 134
hoarseness 115
discomfort 115
discomfort 111
acid regurgitation 109
wheezing 105
dyspnea 105
seizures 94
belching 93
epigastric pain 84
postnasal drip 83
bloating 76
stridor 65
respiratory distress 60
angina 60
overweight 50
hypotonia 46
ENT 42
erythema 39
headache 37
anorexia 37
spasm 36
persistent cough 36
fatigue 33
sore throat 31
nausea and vomiting 30
weakness 29
cyanosis 29
Wind 27
colic 25
collapse 25
sleepiness 25
Regurgitation 24
dystonia 23
chronic constipation 23
incoordination 22
insomnia 21
syncope 17
nocturnal cough 17
snoring 16
Gastrointestinal symptoms 16
retching 16
torticollis 15
spasticity 15
back pain 15
Respiratory symptoms 14
analgesia 14
dizziness 13
ENT symptoms 13
atypical chest pain 12
drooling 12
Ill 11
hemoptysis 11
hypertonia 11
hypercapnia 10
shortness of breath 10
paresis 10
distraction 9
cachexia 9
agitation 9
tremor 8
Non-cardiac chest pain 8
exertional dyspnea 7
hepatosplenomegaly 7
hypothermia 7
chest tightness 7
abdominal discomfort 7
pallor 7
hunger 7
stomach pain 6
tachypnea 6
hepatomegaly 6
ataxia 6
voice change 6
arthralgia 6
bitter taste 6
acute abdomen 5
halitosis 5
productive cough 5
non-productive cough 5
otalgia 5
splenomegaly 5
lethargy 5
low back pain 5
acute abdominal pain 5
clubbing 5
abdominal cramps 4
retrosternal discomfort 4
starvation 4
hyperemesis gravidarum 4
hypoproteinemia 4
decreased appetite 4
muscle cramps 4
myoclonus 4
nasal congestion 4
night sweats 4
thinning 4
paresthesia 4
polyuria 4
aphonia 4
tinnitus 3
Infantile colic 3
alexithymia 3
neurological disability 3
dysarthria 3
lightheadedness 3
Motor dysfunction 3
facial pain 3
exertional chest pain 3
numbness 3
throat irritation 3
Esophageal pain 3
flank pain 3
flushing 3
Early satiety 2
paraparesis 2
nasal discharge 2
rhinorrhea 2
Visceral pain 2
vertigo 2
muscle stiffness 2
hot flashes 2
Bilious vomiting 2
Poor weight gain 2
cancer pain 2
body pain 2
Esophageal chest pain 2
dry skin 2
Globus sensation 2
blepharospasm 2
Floppy 2
exhaustion 2
Swallowing problems 2
painful swallowing 2
enuresis 2
bone pain 2
Spastic 2
Postoperative nausea and vomiting 2
excessive sweating 2
eds 2
tingling 2
functional recovery 2
muscular incoordination 2
polydipsia 2
rales 2
asthenia 2
intestinal bleeding 2
epigastric distress 2
more...
Drug
Asthma 143
Omeprazole 118
Cardiovasc 88
Cisapride 48
ENT 42
Gastro 36
Ranitidine 24
caffeine 18
Cimetidine 15
Cimetidine 14
Monit 13
Histamine 10
ascorbate 10
lactose 10
Nexium 10
Sucralfate 9
Pariet 8
Leaf 8
ROC 7
Domperidone 7
citric acid 7
nitroglycerin 6
Primperan 6
Theophylline 6
Allergen 6
Dial 6
Atropine 6
CSF 6
DEL 6
Botox 6
Azithromycin 5
Pantoprazole sodium 5
ampicillin 5
ROS 5
Misoprostol 4
ADM 4
OTC 4
OTC 4
Gel 3
GNA 3
Bifidobacterium 3
Sodium alginate 3
Ethanol 3
EDR 3
Scopolamine 3
Diurnal 3
Maalox 3
Protonix 3
Propulsid 3
Dakar 3
IL-1ra 3
Fraction 3
Buscopan 3
Dermatol 3
TAK 3
Lugol 2
Itopride hydrochloride 2
IFN-gamma 2
Glucagon 2
Glutathione 2
Clonidine 2
Pirfenidone 2
Atrovent 2
Histalog 2
Omalizumab 2
OMP 2
Vitamin B12 2
Methylene blue 2
Tegaserod 2
ACT 2
Propofol 2
lysine 2
IL-2 2
Hypaque 2
Vicryl 2
Gabapentin 2
Tenatoprazole 2
Ipratropium bromide 2
PTH 2
Citric acid 2
EPI 2
Tegaserod 2
Triclosan 2
Diphenhydramine 2
vitamin E 2
Mirtazapine 2
Plaquenil 1
Infliximab 1
DMSA 1
Glycerol 1
Metoclopramide hydrochloride 1
Simvastatin 1
Spectrum 1
Carafate 1
Histalog 1
Mepolizumab 1
Nedocromil sodium 1
EE2 1
Pepstatin 1
Fosamax 1
Singulair 1
Ranitidine hydrochloride 1
Alendronate sodium 1
CSI 1
Hypaque 1
Gelfoam 1
Bupivacaine 1
PCB 1
Doxycycline 1
Clebopride 1
CaCl2 1
CTX 1
ABC 1
AmBisome 1
Adalimumab 1
Plaquenil 1
CEG 1
Galactose 1
Asn 1
NVP 1
Zinga 1
CEG 1
Darvon 1
Rebamipide 1
APD 1
Clopidogrel 1
PFA 1
Lugol's solution 1
Capsicum 1
Catapres 1
Dextropropoxyphene 1
Thioproline 1
Ouabain 1
AIC 1
TES 1
Gastrozepin 1
SBT 1
Dimethicone 1
Enprofylline 1
Muse 1
Singular 1
Sorafenib 1
Sincalide 1
Nephron 1
Calcium chloride 1
EHDP 1
CIA 1
Sevelamer carbonate 1
Alliance 1
Prednisolone 1
NH3 1
Tilade 1
Gastrozepin 1
Aminoguanidine 1
Cordarone 1
Poloxamer 188 1
RSM 1
Mycophenolic acid 1
Fluorescein 1
Norcuron 1
more...
Enzyme
pepsin 129
ATPase 57
urease 28
urease 28
trypsin 27
ACE 20
mitogen-activated protein kinase 17
ERK 17
CYP3A4 13
phosphodiesterase 11
peroxidase 10
protein kinase C 7
superoxide dismutase 7
catalase 7
alanine aminotransferase 6
lipase 6
aspartate aminotransferase 6
NO synthase 5
APC 5
glutathione peroxidase 5
tryptase 5
lactase 4
ornithine transcarbamylase 4
NADPH oxidase 4
BAL 4
MEK 4
NADPH oxidase 4
acetylcholinesterase 4
protein kinase 4
NOS 4
CAD 3
CAD 3
NADPH-diaphorase 3
focal adhesion kinase 3
CAD 3
MIP 3
ACS 3
NQO1 3
glutathione S-transferase 3
luciferase 3
alpha-amylase 2
DCF 2
SOR 2
beta-glucosidase 2
AST 2
myrosinase 2
plasmin 2
IKK 2
CDH 2
endonuclease 2
CD10 2
reverse transcriptase 2
monoamine oxidase 2
myosin light chain kinase 2
phosphatidylinositol 3-kinase 2
PAT 2
elastase 2
glucocerebrosidase 2
PMT 2
beta-glucosidase 2
SOR 2
renin 2
cholinesterase 2
papain 2
carbonic anhydrase 2
AOR 2
RNA polymerase 2
transglutaminase 1
adenosine deaminase 1
TRS 1
proteasome 1
ATP synthase 1
P-glycoprotein 1
transketolase 1
PFI 1
LIS 1
MDP 1
calcineurin 1
aldehyde dehydrogenase 1
demethylase 1
prolyl hydroxylase 1
methylcrotonyl-CoA carboxylase 1
protein phosphatase 2A 1
DNA ligase 1
gastricsin 1
nitrate reductase 1
3-hydroxy-3-methylglutaryl-CoA reductase 1
CPR 1
carboxylesterase 1
GABA transaminase 1
MCS 1
nitrate reductase 1
caspase-9 1
nitrate reductase 1
galactose oxidase 1
cathepsin D 1
deaminase 1
aldose reductase 1
PHOSPHO1 1
diaphorase 1
GCA 1
DNA ligase 1
caspase-3 1
phytase 1
topoisomerase 1
topoisomerase 1
prostate-specific antigen 1
nitrate reductase 1
phytase 1
GDP-mannose 4,6-dehydratase 1
granzyme B 1
phospholipase C 1
N-acetyltransferase 1
nitrate reductase 1
NAT 1
lysyl oxidase 1
ornithine decarboxylase 1
CaMKII 1
tyrosinase 1
nitrate reductase 1
Fpg protein 1
histidine decarboxylase 1
sulfatase 1
transcriptase 1
PST 1
DNase 1
heme oxygenase 1
diaphorase 1
soluble epoxide hydrolase 1
phosphoglycerate dehydrogenase 1
arylsulfatase 1
alkaline phosphatase 1
KAT 1
arylsulfatase A 1
H,K-ATPase 1
flavin-containing monooxygenase 1
GSK 1
adenosine deaminase 1
pantothenate kinase 1
lactate dehydrogenase 1
12-lipoxygenase 1
GDP-L-fucose synthase 1
tyrosine hydroxylase 1
caspase-1 1
GAS 1
SPT 1
chymotrypsin 1
p-nitrophenylphosphatase 1
lipoxygenase 1
Compound
Clin 1205
Dec 802
barium 401
water 170
PPI 135
Omeprazole 122
oxygen 112
DNA 92
nitric oxide 85
calcium 78
sodium 69
potassium 63
His 59
glucose 59
HCl 57
hydrogen 55
Cisapride 46
Rabeprazole 39
CO2 39
GABA 37
GABA 37
iron 33
urea 31
ethanol 30
salt 30
Metoclopramide 28
acetate 26
Lansoprazole 26
Pantoprazole 25
Baclofen 25
Optimal 23
Ranitidine 22
sulfate 21
phosphate 20
Cardiol 19
ASA 18
TNF 18
glutamate 18
caffeine 18
bromide 15
nitrogen 15
ammonia 14
carbonate 14
APO 13
ATP 13
A 3 12
arginine 12
creatinine 12
nitrate 11
gamma-aminobutyric acid 11
PGE2 10
Bethanechol 10
Histamine 10
galactose 10
phosphorus 9
Sucralfate 9
tryptophan 8
Theophylline 8
6-12 8
Pac 8
aluminum 8
Estrogen 8
cysteine 8
Domperidone 8
iodine 8
Alginate 7
Melatonin 7
THE 7
A 1 7
tryptophan 7
NH2 7
Nizatidine 7
PEG 7
zinc 6
Erythromycin 6
acetic acid 6
tryptophan 6
methionine 6
tryptophan 6
vitamin D 6
5-HT 6
Atropine 6
Dial 6
Azithromycin 5
copper 5
Salix 5
Isoproterenol 5
hydroxide 5
pyridine 5
tyrosine 5
TOF 5
Capsaicin 5
serine 5
BMC 5
vinyl 5
PEG 5
prostaglandin E1 5
Insulin 5
isopentenyl diphosphate 5
Prone 4
pyrimidine 4
TEM 4
IDA 4
GSH 4
ACh 4
DES 4
TNM 4
GSH 4
Formal 4
lysine 4
Estrogen 4
PAP 4
Hematoxylin 4
Gly 4
H2S 4
aldehyde 4
sodium chloride 4
BAL 4
HCI 4
hyaluronic acid 4
T 1 4
A 42 4
Collagen 4
pyrimidine 4
PAP 4
NADPH 3
L-DOPA 3
SEE 3
Glutamate 3
TIF 3
Substance P 3
Bismuth 3
silver 3
Nifedipine 3
acrylamide 3
Angiotensin II 3
Salt 3
ACS 3
Morphine 3
mercury 3
Phe 3
Methotrexate 3
Parenteral 3
Pirenzepine 3
ITP 3
BRL 3
Curcumin 3
DTPA 3
GDP 3
NADPH 3
PGE 3
Guo 3
butyric acid 3
Rabeprazole sodium 3
TSH 3
ACTH 3
N-acetylcysteine 3
PAS 3
Pentagastrin 3
DCI 3
more...