Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0017168 (gastroesophageal reflux disease)
 11,783 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Described is an original technic in which water is used in conjunction with the barium examination of the upper gastrointestinal tract. After the routine barium examination, the ingestion of water through a straw with a hole in it, while the patient is upright, results in a triple-contrast study of the stomach. The technic has proven useful in: (1) demonstrating all types of benign and malignant lesions in the stomach, pyloric valve, and duodenum; (2) showing benign and malignant lesions, inaccessible to palpation, in the fundus and upper portions of the stomach body; (3) demonstrating "occult" ulcers when the water washes away all of the barium except that which for some unknown reason remains within the ulcer crater; (4) examining the postoperative stomach, particularly when marginal ulceration is suspected after subtotal gastrectomy; and (5) demonstrating hiatal hernias and gastroesophageal reflux. A modified technic is used for patients who can only be examined in the recumbent position.
 ...
PMID:Use of water in the examination of the upper gastrointestinal tract. 91 Jan 75

The aim of the present study was to evaluate pressure changes of the UES under conditions that simulate the effects of gastroesophageal reflux (GER), that are, balloon esophageal distension and acid perfusion 0.1 N. Studies were performed in eight healthy subjects and fourteen patients with reflux esophagitis (RE), divided in two groups according to symptoms, 6 patients with heartburn and 8 patients with heartburn and regurgitation. We have employed the Dent sleeve to monitor UES pressure. The catheter was located with the help of a side-hole manometric catheter placed in the opposite side of the Dent sleeve; thereafter, it was anchorated. Perfusion of acid at 5 and 10 cm below the UES induces a pressure increase statistically significant, (paired data). This pressure increase is shown when mean values of the 5 minutes are considered as well for every minute. On the after hand, esophageal balloon distension did not produce pressure increases in any of the groups.
 ...
PMID:[Continuous monitoring of the upper esophageal sphincter with the Dent device, during acid perfusion or distension with balloon of the esophageal body]. 159 60

The advantage of a single-lumen end-hole catheter compared with the usual composite side-hole catheter for lower esophageal sphincter (LES) manometry has been studied in vitro and in vivo. In the present study LES pull-through manometry was performed with a special catheter, enabling simultaneous end-hole and side-hole recording of LES pressure. Eighteen normal individuals with normal 24-h pH-monitoring (control group) and 42 reflux patients with pathologic 24-h pH-monitoring (reflux group) were studied. End-hole recorded resting sphincter pressure (RSP) in the control group was 15.4 +/- 5.0 cm H2O and in the reflux group 6.4 +/- 6.4 (p less than 0.0005). Side-hole recorded RSP (mean S1-S3) was 20.8 +/- 11.6 and 11.9 +/- 6.8, respectively (p less than 0.005). End-hole recorded total sphincter length (SL) in the control group was 34 +/- 9 mm and in the reflux group 27 +/- 12 (p less than 0.025) and abdominal sphincter length (ASL) 23 +/- 7 and 16 +/- 9, respectively (p less than 0.005). Side-hole recorded SL was 30 +/- 7 and 30 +/- 12, respectively (NS) and ASL 22 +/- 6 and 18 +/- 9 respectively (NS). After intake of 500 ml of water both LES pressure and length decreased in both groups but the separation between the groups was neither improved nor impaired. The results support the view that LES insufficiency is an important cause of gastroesophageal reflux. That LES had a lower pressure and was shorter in patients with reflux was best demonstrated by end-hole recorded pressure.
 ...
PMID:Lower esophageal sphincter pressure in normal individuals and patients with gastroesophageal reflux. A comparison between end-hole and side-hole recording techniques. 279 87

The purpose of our research was to study the patients' quality of life after different traditional and laparoscopic, partial--180, 270 and complete 360 surgical operations in cases of diaphragm esophagus hole hernia and the gastroesophageal reflux disease (GERD).
 ...
PMID:[Quality of life of patients after antireflux surgery]. 1462 18